ArticleFrontiers in oncology2026
Case Report: Refractory desmoplastic small round cell tumor: a report of a molecularly confirmed case with
Article in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Desmoplastic small round cell tumor (DSRCT) is an extremely rare and highly aggressive soft-tissue sarcoma that predominantly affects adolescents and young male patients. This malignancy is defined by the t(11;22) (p13;q12) chromosomal translocation, which generates the Case summary: A 13-year-old boy presented with increased defecation frequency and progressive weight loss. Serum cancer antigen 125 (CA125) levels were markedly elevated at 187.00 U/mL. Contrast-enhanced abdominal computed tomography (CT) revealed a large heterogeneous mass with calcifications in the left epigastrium, invading the adjacent intestinal loops. CT-guided biopsy combined with immunohistochemical staining demonstrated positive expression of desmin, cytokeratin pan (CKpan), and vimentin in the tumor. Targeted next-generation sequencing (NGS) confirmed the presence of Conclusion: We report a pediatric case of intra-abdominal DSRCT harboring
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