Diagnostic performance of serum vitamin D metabolites and 14 inorganic elements in early prediction of kidney neoplasm.

Chunmei Dai, Bin Zhang, Qiang Deng, Jiafu Feng

Abstract read

In one paragraph

Article in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Chunmei Dai *Department of Clinical Laboratory, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, China.

Bin Zhang *Department of Clinical Laboratory, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, China.

Qiang DengDepartment of Clinical Laboratory, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, China.

Jiafu FengDepartment of Clinical Laboratory, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: This study aimed to identify potential biomarkers by profiling serum vitamin D (VitD) metabolites and fourteen trace elements, with the goal of screening kidney neoplasm (KN) before symptom onset. Methods: The study included 57 renal cell carcinoma (RCC) patients, 43 patients with benign KN (BKN), and 50 healthy controls. Serum levels of VitD metabolites, including 25(OH)D Results: RCC and BKN patients exhibited significantly lower serum levels of t-25(OH)D, 25(OH)D Conclusion: KN patients exhibit altered VitD metabolites and trace element profiles, with low Zn and Se potentially promoting malignancy. Free-25(OH)D, Fe, and Zn serve as protective factors, while C3-epi predisposes to disease. Combining C3-epi with f-25(OH)D and Zn, or with Fe and Zn, provides strong diagnostic accuracy for KN.

Indexed as

C3-epimerinorganic elementskidney neoplasmrenal cell carcinomavitamin D

Identifiers

PMID42558352

DOI10.3389/fonc.2026.1884903

PMCPMC13437426

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.