ArticleFrontiers in cardiovascular medicine2026
Aortic manipulation proxy score predicts early stroke after isolated coronary artery bypass grafting: an international multicenter cohort study.
Article in Frontiers in cardiovascular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Stroke remains a devastating complication after coronary artery bypass grafting (CABG), often related to intraoperative aortic manipulation and embolization. However, no simple and scalable surrogate exists to approximate procedural complexity and embolic risk using routinely collected variables. We developed and evaluated the Aortic Manipulation Proxy (AMP) score for predicting 30-day stroke after isolated CABG. Methods: We conducted a retrospective international multicenter cohort study including 6,818 adults undergoing isolated CABG. The primary outcome was 30-day postoperative stroke ( Results: Higher AMP scores were associated with a graded increase in 30-day stroke risk. In center-stratified models, AMP independently predicted stroke per 1-SD increase (HR 1.46; 95% CI, 1.23-1.73; Conclusions: In a large multicenter CABG cohort, the AMP score was independently associated with 30-day stroke and provided incremental risk stratification beyond conventional clinical factors. As a pragmatic surrogate derived from routinely available data, the AMP score may support early postoperative risk assessment, although external validation is warranted.
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