ReviewFrontiers in nutrition2026
Modulating gut microbial biofilms for intestinal barrier repair: opportunities in nutritional intervention.
Review in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The gut microbiota has emerged as a key therapeutic target in clinical nutrition for special medical purposes for repairing intestinal barrier damage. However, current strategies primarily focus on modulating microbial composition while overlooking the functional microbial community structure-particularly biofilms, which play important roles in gut physical, chemical and immune barrier homeostasis. Methods: Relevant literature on nutrition intervention, gut microbiota and biofilm, and intestinal barrier published in PubMed and CNKI up to June 2026 was narratively reviewed. Results: This review systematically analyzes nutrients-biofilm-barrier axis, highlights the function of microbial biofilm formation and interaction involved in barrier integrity, and evaluates innovative nutritional interventions capable of modulating biofilm formation, including with enteral nutrition (EN) and parenteral nutrition (PN). Clinically, we discuss how this biofilm-centric approach offers enhanced clinical outcomes in managing barrier dysfunction associated with diseases such as IBD, compared to conventional microbiota modulation alone. Conclusion: The function of nutrients to effectively modulate the gut microbial biofilm in barrier integrity has been increasingly recognized in recent years. Future research is needed to further explore biofilm-based nutritional interventions and their therapeutic role in disease management.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.