Evidence map›Paper›PMID 42558461›Full record

ReviewFrontiers in immunology2026

From support to homeostatic licensing: the bidirectional fibroblast-macrophage circuit and its central role in tissue homeostasis and fibrosis.

Meng Zhang, Ruiqi Chu, Shengni Zhang, Xiangxiang Ren

Abstract readReview
In one paragraph

Review in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Meng ZhangDepartment of Dermatology, Affiliated Hospital of Hebei University, Baoding, Hebei, China.
Ruiqi ChuDepartment of Dermatology, Affiliated Hospital of Hebei University, Baoding, Hebei, China.
Shengni ZhangDepartment of Dermatology, Affiliated Hospital of Hebei University, Baoding, Hebei, China.
Xiangxiang RenDepartment of General Surgery, Affiliated Hospital of Hebei University, Baoding, Hebei, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The capacity of fibroblasts to support macrophages predominantly through colony-stimulating factor 1 (CSF1)-mediated survival and proliferation has long been recognized. Whether macrophages actively regulate fibroblasts

Indexed as

FibroblastsHomeostasisMacrophagesAnimalsFibrosisHumansMacrophage Colony-Stimulating FactorScleroderma, SystemicSignal TransductionMacrophage Colony-Stimulating Factorbidirectional regulationcell nicheCSF1–CSF1R axisfibroblastsfibrosishomeostatic licensingmacrophagestissue homeostasis

Identifiers

PMID42558461
PMCPMC13437770

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.