Evidence map›Paper›PMID 42558860›Full record

ArticleSAGE open medicine2026

HMGA1 is associated with unfavorable outcome and accelerates the aggressiveness of cholangiocarcinoma.

Ratthaphong Phumphu, Saowaluk Saisomboon, Piya Prajumwong, Orawan Waenphimai, Kulthida Vaeteewoottacharn, Sopit Wongkham, Ubon Cha'on, Charupong Saengboonmee, Anucha Puapairoj, Chawalit Pairojkul and 3 more

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Article in SAGE open medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ratthaphong PhumphuDepartment of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Saowaluk SaisomboonDepartment of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Piya PrajumwongDepartment of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Orawan WaenphimaiDepartment of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Kulthida VaeteewoottacharnDepartment of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Sopit WongkhamDepartment of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Ubon Cha'onDepartment of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.ORCID https://orcid.org/0000-0002-9909-8671
Charupong SaengboonmeeDepartment of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.ORCID https://orcid.org/0000-0003-1476-1129
Anucha PuapairojDepartment of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Chawalit PairojkulDepartment of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Ryusho KariyaDivision of Hematopoiesis, Joint Research Center for Human Retrovirus Infection and Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
Seiji OkadaDivision of Hematopoiesis, Joint Research Center for Human Retrovirus Infection and Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
Kanlayanee SawanyawisuthDepartment of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.ORCID https://orcid.org/0000-0003-2260-6372

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Cholangiocarcinoma (CCA) is a highly metastatic bile duct cancer with the highest global incidence in Northeastern Thailand. Most patients are diagnosed at advanced stages, necessitating the identification of novel prognostic markers and therapeutic targets. High mobility group A1 (HMGA1) is a non-histone chromosomal protein that orchestrates the transcription of genes involved in tumor progression, and its overexpression has been implicated in multiple malignancies. Methods: HMGA1 expression was evaluated in a hamster CCA model and human CCA tissues using immunohistochemistry. The functional effects of HMGA1 on cell growth, migration, and invasion, along with the underlying molecular mechanisms were investigated Results: HMGA1 upregulation was detected as an early event in the cholangiocarcinogenesis of a hamster model. In the human cohort (n = 81), high HMGA1 expression significantly correlated with histological type (

Indexed as

apoptosischolangiocarcinomaEMTHMGA1invasionmigration

Identifiers

PMID42558860
PMCPMC13438342

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.