ArticleNagoya journal of medical science2026
Coefficient of variation of R-R intervals during deep breathing as a risk marker of orthostatic blood pressure decline in patients with Type 2 diabetes mellitus.
Article in Nagoya journal of medical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Diabetic orthostatic hypotension, associated with cardiovascular autonomic neuropathy, can be assessed using the coefficient of variation of the R-R interval (CVRR). We investigated whether CVRR during deep breathing could serve as a risk indicator for orthostatic blood pressure decline in patients with type 2 diabetes. This study included 88 hospitalized patients aged 51.5-71.4 years with type 2 diabetes undergoing diabetes education or glycemic control. Blood pressure changes during postural transitions were measured using a non-invasive beat-to-beat blood pressure monitoring device. Participants were divided into two groups based on CVRR values measured at rest and during deep breathing, using a cutoff of 2%. Blood pressure changes during postural transitions were compared. At rest, no significant differences in systolic or diastolic blood pressure changes were observed between the autonomic dysfunction group (CVRR ≤ 2%, n = 42) and the non-autonomic dysfunction group (CVRR >2%, n = 46;
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