Evidence map›Paper›PMID 42559043›Full record

ArticleFrontiers in immunology2026

Host genetics influences HIV reservoir persistence, treatment outcomes and CCR5 expression in patients on long-term antiretroviral therapy in Ghana.

Peter Kwabena Appiah, Evelyn Yayra Bonney, Christian Obirikorang, James Odame Aboagye, Mildred Egyirba Hanson, Samuel Kwame Sopuruchi Agomuo, Alfred Effah, Max Efui Annani-Akollor, George Boateng Kyei

Abstract read
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In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Peter Kwabena AppiahNoguchi Memorial Institute of Medical Research, University of Ghana, Legon, Ghana.
Evelyn Yayra BonneyNoguchi Memorial Institute of Medical Research, University of Ghana, Legon, Ghana.
Christian ObirikorangDepartment of Molecular Medicine, School of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
James Odame AboagyeNoguchi Memorial Institute of Medical Research, University of Ghana, Legon, Ghana.
Mildred Egyirba HansonNoguchi Memorial Institute of Medical Research, University of Ghana, Legon, Ghana.
Samuel Kwame Sopuruchi AgomuoDepartment of Molecular Medicine, School of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
Alfred EffahDepartment of Molecular Medicine, School of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
Max Efui Annani-AkollorDepartment of Molecular Medicine, School of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
George Boateng KyeiNoguchi Memorial Institute of Medical Research, University of Ghana, Legon, Ghana.

Funding

"Viral and latent HIV reservoir characteristics in HIV patients with persistent low-level viremiaR21AI174880 · NIAID · NOGUCHI MEMORIAL INSTITUTE / MEDICAL RES · PI BONNEY, EVELYN YAYRA · 2023 to 2024
$290k
NIAID NIH HHS R21 AI174880
6 · The paper itself

Abstract

Objective: This study investigated influence of cysteine-cysteine chemokines (CCR5, CCR5-59029A/G, CCR2), and stoma cell derived factor 1 (SDF1); as AIDS restriction genes (ARGs), on treatment outcomes among people with HIV (PWH) on long term antiretroviral therapy (ART) in Ghana. Methods: This cross-sectional study was conducted among 167 PWH and receiving ART in Accra, Ghana. Genomic DNA from PBMCs was used to genotype CCR5-Δ32, CCR2-V64I, CCR5 A59029G, and SDF1-3'A variants using polymerase chain reaction-restriction fragment length polymorphism, CCR5 expression was estimated by RT-qPCR. Results: All participants carried the wild-type CCR5 genotype. No AIDS Restriction Genes was associated with virologic or immunological outcomes ( Conclusion: No ARG variant was significantly associated with virologic or immunological outcomes. However, CCR5 A59029G was associated with differences in proviral DNA burden and CCR5 mRNA expression, suggesting a potential role in HIV reservoir dynamics during suppressive ART.

Indexed as

HIV-1HIV InfectionsReceptors, CCR5AdultAntiretroviral Therapy, Highly ActiveChemokine CXCL12Cross-Sectional StudiesFemaleGenotypeGhanaHumansMaleMiddle AgedTreatment OutcomeViral LoadCCR5 protein, humanChemokine CXCL12Receptors, CCR5AIDS restriction genesantiretroviral therapyCCR5 polymorphismsHIV latent reservoirhuman immunodeficiency virusSDF1-3′A

Identifiers

PMID42559043
PMCPMC13438377

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.