ReviewFrontiers in endocrinology2026
Regulation of osteoclastogenesis and bone resorption by fatty acid metabolism: mechanisms and therapeutic opportunities.
Review in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Bone marrow adipoq-lineage cells in regulating the bone and marrow microenvironment: identities, functions, and mechanisms.Frontiers in endocrinology · 2026Review
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bone remodeling is orchestrated by osteoclast-mediated resorption and osteoblast-mediated formation. Dysregulated hyperactivity of osteoclasts is a central driver of pathological bone loss in multiple osteolytic diseases, such as postmenopausal osteoporosis, rheumatoid arthritis, and peri-implant osteolysis. Although the core RANKL signaling cascade that governs osteoclast differentiation has been well characterized, accumulating evidence indicates that RANKL also triggers profound metabolic reprogramming during osteoclastogenesis, among which fatty acid (FA) metabolism has emerged as a critical regulator of osteoclast fate and function. In this review, we provide a comprehensive analysis of how FA metabolic pathways regulate osteoclast differentiation, fusion, and function. We first briefly introduce the core FA metabolic pathways relevant to osteoclasts, including FA uptake, FA oxidation, FA storage,
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.