ArticleTheranostics2026
The role of an ultrasound-responsive injectable piezoelectric hydrogel in promoting nerve regeneration and alleviating neuropathic pain.
Article in Theranostics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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21 authors.
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Abstract
Background: Neuropathic pain (NP) resulting from peripheral nerve injury (PNI) represents a major clinical challenge. Although electrical stimulation (ES) has demonstrated therapeutic benefits, its clinical translation is limited by the invasiveness of electrode implantation, which often requires large surgical incisions and percutaneous wiring, increasing tissue damage and infection risk. Methods: This study developed an ultrasound-responsive, injectable, and biodegradable piezoelectric hydrogel (sPLLA-Gel) composed of electrospun poly-L-lactic acid (PLLA) and methacryloyl gelatin (GelMA). The physicochemical characteristics, biocompatibility, and piezoelectric performance were systematically evaluated. Results: The sPLLA-Gel hydrogel exhibited excellent injectability, biodegradability, and ultrasound-induced electrical responsiveness. Conclusions: This study demonstrates the potential of this ultrasound-responsive piezoelectric hydrogel to promote peripheral nerve regeneration and mitigate NP, offering a promising minimally invasive strategy for treating sciatic nerve injury-related NP.
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