Evidence map›Paper›PMID 42559260›Full record

ArticleFrontiers in microbiology2026

Qin Yin, Jun Gu, Ruijun Bai, Kai Zhao, Qiubo Wang, Yanbin Liu, Yu Liu, Haifeng Li

Abstract read
In one paragraph

Article in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Qin YinDepartment of Orthopedics, Wuxi Ninth People's Hospital Affiliated to Soochow University, Wuxi, Jiangsu, China.
Jun GuDepartment of Orthopedics, Wuxi Ninth People's Hospital Affiliated to Soochow University, Wuxi, Jiangsu, China.
Ruijun BaiDepartment of Orthopedics, Wuxi Ninth People's Hospital Affiliated to Soochow University, Wuxi, Jiangsu, China.
Kai ZhaoDepartment of Orthopedics, Wuxi Ninth People's Hospital Affiliated to Soochow University, Wuxi, Jiangsu, China.
Qiubo WangDepartment of Orthopedics, Wuxi Ninth People's Hospital Affiliated to Soochow University, Wuxi, Jiangsu, China.
Yanbin LiuDepartment of Orthopedics, Wuxi Ninth People's Hospital Affiliated to Soochow University, Wuxi, Jiangsu, China.
Yu LiuDepartment of Orthopedics, Wuxi Ninth People's Hospital Affiliated to Soochow University, Wuxi, Jiangsu, China.
Haifeng LiDepartment of Orthopedics, Wuxi Ninth People's Hospital Affiliated to Soochow University, Wuxi, Jiangsu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Plant-derived nanovesicles (NVs) have emerged as promising natural nanotherapeutics for metabolic and inflammatory diseases due to their inherent biocompatibility, multi-target potential, and ability to mediate cross-kingdom communication. Postmenopausal osteoporosis (PMOP), a prevalent skeletal disorder driven by estrogen deficiency, is characterized by gut-bone axis dysregulation, chronic inflammation, and excessive oxidative stress-pathological features that demand synergistic multi-target interventions. This study aimed to characterize Methods: PQs were isolated via modified differential centrifugation and characterized using transmission electron microscopy (TEM), nanoparticle tracking analysis (NTA), and high-performance liquid chromatography (HPLC). Their bone-targeting capacity was evaluated via Results: PQs exhibited a typical cup-shaped morphology (mean diameter ~89 nm), negative zeta potential (-42.21 ± 0.12 mV), and stable batch-to-batch naringin content (0.65 ± 0.03 μg/mL). Conclusion:

Indexed as

gut-bone axisgut microbiotaMYC pathwaynanovesiclesNrf2/HO-1osteoporosisoxidative stressPanax quinquefolius

Identifiers

PMID42559260
PMCPMC13440151

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.