Evidence mapPaperPMID 42560404Full record

ReviewCurrent atherosclerosis reports2026

Sphingolipids and Atherosclerosis.

Xiang Li, Zhiqiang Li, Xian-Cheng Jiang

Abstract readReview
In one paragraph

Review in Current atherosclerosis reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Xiang LiDepartment of Cell Biology, State University of New York Downstate Health Sciences University, Brooklyn, NY, USA.
Zhiqiang LiDepartment of Cell Biology, State University of New York Downstate Health Sciences University, Brooklyn, NY, USA.
Xian-Cheng JiangDepartment of Cell Biology, State University of New York Downstate Health Sciences University, Brooklyn, NY, USA. xjiang@downstate.edu.ORCID https://orcid.org/0000-0003-2030-9542

Funding

Effect of sphingomyelin biosynthesis on atherosclerosisR01HL149730 · NHLBI · SUNY DOWNSTATE MEDICAL CENTER · PI XIAN-CHENG JIANG · 2022 to 2023
$964k
BLRD VA I01 BX000900NHLBI NIH HHS R01 HL149730NHLBI NIH HHS RO1, HL149730
6 · The paper itself

Abstract

purpose of reviewWe integrate evidences from human and mouse model studies which emphasize sphingolipid metabolism-mediated endothelium-lipoprotein-atherogenic plaque framework. The review may provide a new angel for understanding the development of atherosclerosis and its prevention and treatment. RECENT

findingsSphingolipids, such as ceramide, sphingomyelin, glucosylceramide, sphingosine-1-phosphate, are one of the major players in atherogenesis. Atherosclerosis begins when ApoB-containing lipoproteins accumulate and undergo modification in the subendothelial space and then progresses through endothelial dysfunction, leukocyte recruitment, foam-cell formation, and plaque formation. Sphingolipids participate in each of these stages both as structural membrane components and as signaling molecules. In this review, we highlight recent advances in sphingolipid biomarkers and discuss their clinical promise and limitations.

Indexed as

AtherosclerosisPlaque, AtheroscleroticSphingolipidsAnimalsBiomarkersEndothelium, VascularHumansLysophospholipidsSphingosineBiomarkersLysophospholipidsSphingolipidsSphingosinesphingosine 1-phosphateAtherosclerosisCeramideLipoproteinsSphingolipid biosynthesisSphingolipidsSphingomyelinSphingosine-1-phosphate

Identifiers

PMID42560404
PMCPMC13472154

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.