Evidence map›Paper›PMID 42560463›Full record

ArticleProbiotics and antimicrobial proteins2026

Protective Effects of Double-layered Multinucleated Microcapsules Containing Bifidobacterium adolescentis FS2-3 Against Enteritis Mediated by Different Pathogens.

Jiayi Tang, Henan Zhang, Danli Yan, Tong Li, Zijing Li, Yulian Zhao, Ying Wang, Feiyu An, Jia Guo, Kexin Zheng and 3 more

Abstract read
PubMed Publisher
In one paragraph

Article in Probiotics and antimicrobial proteins, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jiayi Tang *College of Food Science, Liaoning Engineering Research Center of Food Fermentation Technology, Shenyang Key Laboratory of Microbial Fermentation Technology Innovation, Shenyang Agricultural University, National Agricultural Environmental Microbial Germplasm Resource Bank, Shenyang, PR China.
Henan Zhang *College of Food Science, Liaoning Engineering Research Center of Food Fermentation Technology, Shenyang Key Laboratory of Microbial Fermentation Technology Innovation, Shenyang Agricultural University, National Agricultural Environmental Microbial Germplasm Resource Bank, Shenyang, PR China.
Danli YanCollege of Food Science, Liaoning Engineering Research Center of Food Fermentation Technology, Shenyang Key Laboratory of Microbial Fermentation Technology Innovation, Shenyang Agricultural University, National Agricultural Environmental Microbial Germplasm Resource Bank, Shenyang, PR China.
Tong LiCollege of Food Science, Liaoning Engineering Research Center of Food Fermentation Technology, Shenyang Key Laboratory of Microbial Fermentation Technology Innovation, Shenyang Agricultural University, National Agricultural Environmental Microbial Germplasm Resource Bank, Shenyang, PR China.
Zijing LiCollege of Food Science, Liaoning Engineering Research Center of Food Fermentation Technology, Shenyang Key Laboratory of Microbial Fermentation Technology Innovation, Shenyang Agricultural University, National Agricultural Environmental Microbial Germplasm Resource Bank, Shenyang, PR China.
Yulian ZhaoCollege of Food Science, Liaoning Engineering Research Center of Food Fermentation Technology, Shenyang Key Laboratory of Microbial Fermentation Technology Innovation, Shenyang Agricultural University, National Agricultural Environmental Microbial Germplasm Resource Bank, Shenyang, PR China.
Ying WangCollege of Food Science, Liaoning Engineering Research Center of Food Fermentation Technology, Shenyang Key Laboratory of Microbial Fermentation Technology Innovation, Shenyang Agricultural University, National Agricultural Environmental Microbial Germplasm Resource Bank, Shenyang, PR China.
Feiyu AnCollege of Food Science, Liaoning Engineering Research Center of Food Fermentation Technology, Shenyang Key Laboratory of Microbial Fermentation Technology Innovation, Shenyang Agricultural University, National Agricultural Environmental Microbial Germplasm Resource Bank, Shenyang, PR China.
Jia GuoCollege of Food Science, Liaoning Engineering Research Center of Food Fermentation Technology, Shenyang Key Laboratory of Microbial Fermentation Technology Innovation, Shenyang Agricultural University, National Agricultural Environmental Microbial Germplasm Resource Bank, Shenyang, PR China.
Kexin ZhengCollege of Food Science, Liaoning Engineering Research Center of Food Fermentation Technology, Shenyang Key Laboratory of Microbial Fermentation Technology Innovation, Shenyang Agricultural University, National Agricultural Environmental Microbial Germplasm Resource Bank, Shenyang, PR China.
Natalia Alekseevna GolovnevaInstitute of Microbiology of the National Academy of Sciences of Belarus, Minsk, Belarus.
Junrui WuCollege of Food Science, Liaoning Engineering Research Center of Food Fermentation Technology, Shenyang Key Laboratory of Microbial Fermentation Technology Innovation, Shenyang Agricultural University, National Agricultural Environmental Microbial Germplasm Resource Bank, Shenyang, PR China. junruiwu@126.com.
Rina WuCollege of Food Science, Liaoning Engineering Research Center of Food Fermentation Technology, Shenyang Key Laboratory of Microbial Fermentation Technology Innovation, Shenyang Agricultural University, National Agricultural Environmental Microbial Germplasm Resource Bank, Shenyang, PR China. wrn6956@163.com.

Funding

Introduction of talents (high-level) research start-up fund project of Shenyang Agricultural University 2023YJRC002Liaoning Province Science and Technology Plan Project 101900005Liaoning Province Science and Technology Plan Project 2024JH2Liao Ning Revitalization Talents Program XLYC2213026Shenyang Science and technology innovation platform project 21-103-0-14
6 · The paper itself

Abstract

Bifidobacterium adolescentis (B. adolescentis), a dominant probiotic in the gut of infants and healthy adults, exerts protective effects on immune development and disease prevention. However, the intervention capability of B. adolescentis against different pathogenic bacteria remains unclear. In this study, we verified that B. adolescentis FS2-3 showed inhibitory effects against five common pathogenic bacteria, including Shigella dysenteriae CMCC 51,252, Klebsiella pneumoniae NCTC 13,440, Pseudomonas aeruginosa CMCC 10,104, Salmonella enteritidis CMCC 50,746, and Campylobacter jejuni CICC 22,936. To improve its intestinal colonization efficiency, we constructed double-layered multinucleated microcapsules (probiotic microcapsules) of B. adolescentis FS2-3 and evaluated their effects on bacterial enteritis induced by five representative foodborne pathogens. The in vitro experiments showed that the survival rate of B. adolescentis FS2-3 in the microcapsules was increased by 5.76 times compared with the unencapsulated strain. Additionally, the probiotic microcapsules significantly reduced intestinal tissue damage and inflammation in all enteritis mice, especially in Salmonella-infected mice. Specifically, the probiotic microcapsules reversed the abnormal bacterial composition by promoting the colonization of beneficial bacteria Bifidobacterium, Alloprevotella, and Lachnospiraceae. Furthermore, the probiotic microcapsules inhibited the overexpression of TLR-4 and reduced the expression of inflammatory mediators, including IL-1β, NF-κB, and TNF-α. These findings provide new insights into the application of probiotic microcapsules in the treatment of enteritis.

Indexed as

BifidobacteriumEnteritisGut microbiotaInflammationMicrocapsule

Identifiers

PMID42560463

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.