Evidence map›Paper›PMID 42560501›Full record

ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2026

Psalmotoxin-1, a novel TRPM2 channel antagonist, reduces age-related macular degeneration-caused mitochondrial oxidative damage and apoptosis in human retinal pigment epithelial (ARPE-19) cells.

Dilek Özkaya, Mustafa Nazıroğlu

Abstract read
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In one paragraph

Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Dilek ÖzkayaDepartment of Ophthalmology, Medical Faculty, Suleyman Demirel University, Isparta, Türkiye.ORCID http://orcid.org/0000-0002-3523-8479
Mustafa NazıroğluNeuroscience Research Center (NOROBAM), Suleyman Demirel University, Isparta, Türkiye. mustafanaziroglu@sdu.edu.tr.ORCID http://orcid.org/0000-0003-0887-6974

Funding

BSN Health, Analyses, Innovation, Consultancy, Organization, Agriculture, Industry LTD, Isparta, Türkiye 2024-05
6 · The paper itself

Abstract

purposeAge-related macular degeneration (AMD) develops as a result of mitochondrial reactive oxygen species (mitROS) and apoptosis caused by increased Ca MATERIALS AND

methodsControl (CONT), 20 nM PSTX for 24 h, 10 mM SoI for 24 h, SoI + PSTX, and SoI + TRPM2 antagonist (25 µM N-(p-amylcinnamoyl) anthranilic acid, ACA) groups were induced in the ARPE-19 cells.

resultsThe ADP-ribose-induced TRPM2 current density, Fe

conclusionThe results of the preliminary study indicated that PSTX incubation blocked TRPM2-mediated Ca

Indexed as

Age-related macular degenerationCell deathMitochondrial oxidant injuryPsalmotoxin-1TRPM2 cation channel

Identifiers

PMID42560501

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.