ArticleGenes & development2026
Neuronal expression of bromodomain proteins alters neuronal health and peripheral protein homeostasis to promote longevity.
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Article in Genes & development, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
28 authors.
Naibedya Dutta *Leonard Davis School of Gerontology, University of Southern California, Los Angeles, California 90089, USA.
Daniel Hicks *Leonard Davis School of Gerontology, University of Southern California, Los Angeles, California 90089, USA.
Edgar EsparzaDepartment of Immunology and Immune Therapeutics, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA.
Anna EntinLeonard Davis School of Gerontology, University of Southern California, Los Angeles, California 90089, USA.
Priyadharshini VijayakumarCenter for Precision Environmental Health, Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA.
Caitlin M LangeCenter for Cardiovascular and Muscular Diseases, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California 92037, USA.
Tripti NairLeonard Davis School of Gerontology, University of Southern California, Los Angeles, California 90089, USA.
Elijah A RoditiLeonard Davis School of Gerontology, University of Southern California, Los Angeles, California 90089, USA.
Athena AlcalaLeonard Davis School of Gerontology, University of Southern California, Los Angeles, California 90089, USA.
Maxim AverbukhLeonard Davis School of Gerontology, University of Southern California, Los Angeles, California 90089, USA.
Matthew VegaLeonard Davis School of Gerontology, University of Southern California, Los Angeles, California 90089, USA.
Rebecca Aviles BarahonaLeonard Davis School of Gerontology, University of Southern California, Los Angeles, California 90089, USA.
Caitlin McTygueLeonard Davis School of Gerontology, University of Southern California, Los Angeles, California 90089, USA.
Veronica KuoLeonard Davis School of Gerontology, University of Southern California, Los Angeles, California 90089, USA.
Juri KimLeonard Davis School of Gerontology, University of Southern California, Los Angeles, California 90089, USA.
Herbert AnsonLeonard Davis School of Gerontology, University of Southern California, Los Angeles, California 90089, USA.
Aeowynn J CoakleyLeonard Davis School of Gerontology, University of Southern California, Los Angeles, California 90089, USA.
George WangAlfred E. Mann School of Pharmacy and Pharmaceutical Sciences, University of Southern California, Los Angeles, California 90033, USA.
Steven E PilleyDepartment of Immunology and Immune Therapeutics, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA.
Max A ThorwaldLeonard Davis School of Gerontology, University of Southern California, Los Angeles, California 90089, USA.
Whitaker CohnAlfred E. Mann School of Pharmacy and Pharmaceutical Sciences, University of Southern California, Los Angeles, California 90033, USA.
Sean P CurranLeonard Davis School of Gerontology, University of Southern California, Los Angeles, California 90089, USA.ORCID http://orcid.org/0000-0001-7791-6453
Nicolas BrouillyCentre National de la Recherche Scientifique (CNRS), Institut de Biologie du Développement de Marseille (IBDM), Aix Marseille University, Marseille 13009, France.
Caroline KumstaCenter for Cardiovascular and Muscular Diseases, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California 92037, USA.
Rachel N AreyCenter for Precision Environmental Health, Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA.ORCID http://orcid.org/0000-0001-9941-3945
Peter J MullenLeonard Davis School of Gerontology, University of Southern California, Los Angeles, California 90089, USA.
Gilberto GarciaLeonard Davis School of Gerontology, University of Southern California, Los Angeles, California 90089, USA; ryo.sanabria@usc.edu gilbertogarcia@usc.edu.
Ryo Higuchi-SanabriaLeonard Davis School of Gerontology, University of Southern California, Los Angeles, California 90089, USA; ryo.sanabria@usc.edu gilbertogarcia@usc.edu.ORCID http://orcid.org/0000-0001-8936-5812
Funding
Wormbase SupplementP41HG002223 · NHGRI · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI STERNBERG, PAUL WARREN · 2000 to 2012
$32.0MWormBase: a core data resource for C. elegans and other nematodesU41HG002223 · NHGRI · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI KERSEY, PAUL, SCHEDL, TIM · 2013 to 2017
$20.5MWormBase: a core data resource for C. elegans and other nematodesU24HG002223 · NHGRI · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI TIM SCHEDL, PAUL Warren STERNBERG · 2018 to 2026
$18.9MEnhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5MUSC Geroscience Training in the Biology of AgingT32AG052374 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Sean P CURRAN · 2016 to 2026
$5.3MUncovering brain-wide molecular determinants of individual memory performance across lifespanDP2NS132372 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI AREY, RACHEL NICOLE · 2022 to 2025
$2.4MAge-dependent SKN-1/NRF cytoprotection at the cost of metabolic homeostasisR01AG058610 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CURRAN, SEAN P · 2019 to 2023
$2.1MWhen actin’s not actin like actin: Nuclear actin impacts transcription and agingR01AG079806 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Ryo Higuchi-Sanabria · 2024 to 2026
$1.9MHormetic regulation of autophagy in agingR01AG083373 · NIA · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI Caroline Kumsta · 2024 to 2026
$1.7MGerontology Enriching MSTEM (GEMSTEM) to Enhance Diversity in AgingR25AG076400 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI AILSHIRE, JENNIFER A, CURRAN, SEAN P · 2022 to 2024
$1.1MMore than just a load control: cytoskeletal form and function during agingR00AG065200 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HIGUCHI-SANABRIA, RYO · 2021 to 2023
$747kNHGRI NIH HHS P41 HG002223NHGRI NIH HHS U24 HG002223NHGRI NIH HHS U41 HG002223NIA NIH HHS R00 AG065200NIA NIH HHS R01 AG058610NIA NIH HHS R01 AG079806NIA NIH HHS R01 AG083373NIA NIH HHS R25 AG076400NIA NIH HHS T32 AG052374NIH HHS P40 OD010440NINDS NIH HHS DP2 NS132372
Abstract
Longevity and stress resilience require precise coordination of gene expression programs across tissues. Here, we demonstrate that overexpression of the chromatin reader
Indexed as
Caenorhabditis elegansCaenorhabditis elegans ProteinsLongevityNeuronsProteostasisAnimalsBromodomain Containing ProteinsForkhead Transcription FactorsGene Expression RegulationHomeostasisSignal TransductionStress, PhysiologicalTranscription FactorsBromodomain Containing ProteinsCaenorhabditis elegans Proteinsdaf-16 protein, C elegansForkhead Transcription FactorsTranscription Factorslongevityneuronsnonautonomous signalingproteostasisstress
Identifiers
What Socratic holds
Textmetadata
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.