Evidence map›Paper›PMID 42562589›Full record

ReviewThe European respiratory journal2026

Preclinical models of COPD: a state of the art review.

Francesca Polverino, Kambez H Benam, Suzanne M Cloonan, Jeffrey L Curtis, Amit Gaggar, Farrah Kheradmand, Mareike Lehmann, Enid Neptune, S Vamsee Raju, Joselyn Rojas-Quintero and 5 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in The European respiratory journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Francesca PolverinoSection of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Baylor College of Medicine, Houston, TX, USA fpolverino@copdnet.org.
Kambez H BenamDivision of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.ORCID https://orcid.org/0000-0001-9117-3959
Suzanne M CloonanSchool of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.
Jeffrey L CurtisInternal Medicine, University of Michigan, Ann Arbor, MI, USA.
Amit GaggarDepartment of Medicine, The University of Alabama at Birmingham, Birmingham, AL, USA.
Farrah KheradmandSection of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Baylor College of Medicine, Houston, TX, USA.
Mareike LehmannInstitute for Lung Research, Philipps-University Marburg, German Center for Lung Research (DZL), Marburg, Germany.ORCID https://orcid.org/0000-0002-8601-8206
Enid NeptuneDivision of Pulmonary and Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA.
S Vamsee RajuDepartment of Medicine, The University of Alabama at Birmingham, Birmingham, AL, USA.ORCID https://orcid.org/0000-0003-3947-4871
Joselyn Rojas-QuinteroSection of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Baylor College of Medicine, Houston, TX, USA.
Maor SaulerYale School of Medicine, Pulmonary, Critical Care and Sleep Medicine, New Haven, CT, USA.ORCID https://orcid.org/0000-0001-5240-7978
Yohannes TesfaigziDivision of Pulmonary and Critical Care Medicine, Mass General Brigham, Harvard Medical School, Boston, MA, USA.
Ali Önder YildirimInstitute of Lung Health and Immunity (LHI), Helmholtz Munich, Comprehensive Pneumology Center (CPC-M), German Center for Lung Research (DZL), Munich, Germany.ORCID https://orcid.org/0000-0003-1969-480X
Anny Xiaobo ZhouDivision of Pulmonary and Critical Care, Center for Translational Genomics, Department of Medicine, Department of Genome Sciences, University of Virginia, Charlottesville, VA, USA.
Don D SinDivision of Respiratory Medicine, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

COPD is a progressive and heterogeneous condition characterised by varying combinations of emphysema, small airway disease, chronic bronchitis and exacerbations. Although multiple symptomatic therapies exist, no disease-modifying treatments are available. This gap highlights the need for improved preclinical models with greater translational relevance. Large human cohorts and single-cell/multi-omics studies have informed the development of current COPD models. We provide a state of the art review of the major experimental platforms:

Indexed as

Disease Models, AnimalPulmonary Disease, Chronic ObstructiveAnimalsDisease ProgressionHumansLungMicrophysiological SystemsMultiomicsOrganoidsPhenotype

Identifiers

PMID42562589

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.