Evidence map›Paper›PMID 42562996›Full record

ReviewDiscover oncology2026

Functional roles and clinical implications of pseudogenes signatures as emerging biomarkers in cancer.

Mohamed Bakr Zaki, Nadia M Hamdy, Mai A Abd-Elmawla, Nehal I Rizk, Doaa Fathi, Nourhan M Abdelmaksoud, Rehab A Ismail, Ahmed S Doghish, Ahmed I Abulsoud

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Discover oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mohamed Bakr ZakiDepartment of Biochemistry, Faculty of Pharmacy, University of Sadat City, Sadat City, 32897, Menoufia, Egypt. mohamed.bakr65@gmail.com.
Nadia M HamdyBiochemistry Department, Faculty of Pharmacy, Ain Shams University, Abassia, Cairo, 11566, Egypt.
Mai A Abd-ElmawlaDepartment of Biochemistry, Faculty of Pharmacy, Cairo University, Kasr Al-Ainy, Cairo, 11562, Egypt.
Nehal I RizkDepartment of Biochemistry, Faculty of Pharmacy and Drug Technology, Egyptian Chinese University, Cairo, 11786, Egypt.
Doaa FathiDepartment of Biochemistry, Faculty of Pharmacy, Alexandria University, Alexandria, 21526, Egypt.
Nourhan M AbdelmaksoudBiochemistry Department, Faculty of Pharmacy, Heliopolis University, Cairo, 11785, Egypt.
Rehab A IsmailBiochemistry Department, Faculty of Pharmacy, Heliopolis University, Cairo, 11785, Egypt.
Ahmed S DoghishDepartment of Biochemistry, Faculty of Pharmacy, Badr University in Cairo (BUC), Cairo, Egypt.
Ahmed I AbulsoudBiochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al Azhar University, Nasr City, Cairo, 11231, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pseudogenes' possible functions in gene control and illness have now come to light. However, it has been recognized that numerous pseudogenes play a critical role in the regulation of their respective parent genes, and it is well-established that pseudogenes influence oncogenes and tumor suppressors. Moreover, pseudogenes are being emphasized for their possible use as diagnostic cancer and prognostic biomarkers. Defining, contextualizing, classifying, and discussing the evolutionary relevance of pseudogenes are all aspects of their complex nature that this article explores. An examination of the clustering and co-expression patterns of pseudogenes, as well as the potential regulatory tasks they may perform, is undertaken. This review seeks to investigate the implications of pseudogenes in various cancer types. Pseudogenes' evolution, biogenesis, and classifications, with in silico analysis, will be reported comprehensively. Additionally, the current review will enumerate the potential of pseudogenes as diagnostic biomarkers and their prognostic significance (good vs. bad) in different cancers. The review elucidated their various functions in cancer and concluded the need for further research to fully understand the roles of pseudogenes in health and disease.

Indexed as

Bioinformatics/in silico analysisCancerCancer biomarkersDiagnosisPrognosisPseudogenesPseudogenes biogenesis

Identifiers

PMID42562996
PMCPMC13447663

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.