Evidence map›Paper›PMID 42563006›Full record

ArticleEuropean journal of clinical nutrition2026

Prognostic value of acylcarnitine-to-free carnitine ratio in ischemic stroke: associations with systemic inflammation and atherosclerosis.

Tsubasa Atsuchi, Motohiro Okumura, Kenichiro Sakai, Yoshitaka Nakayama, Hiroyuki Kida, Ryoji Nakada, Tomomichi Kitagawa, Yuri Mizuno-Shojima, Hiroki Takatsu, Teppei Komatsu and 3 more

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Article in European journal of clinical nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

13 authors.

Tsubasa AtsuchiDepartment of Neurology, The Jikei University School of Medicine, Tokyo, Japan.
Motohiro OkumuraDepartment of Neurology, The Jikei University School of Medicine, Tokyo, Japan. kuromaru.mate@gmail.com.ORCID http://orcid.org/0000-0003-1973-4816
Kenichiro SakaiDepartment of Neurology, The Jikei University School of Medicine, Tokyo, Japan.
Yoshitaka NakayamaDepartment of Neurology, The Jikei University School of Medicine West Medical Center, Tokyo, Japan.
Hiroyuki KidaDepartment of Neurology, The Jikei University School of Medicine, Tokyo, Japan.
Ryoji NakadaDepartment of Neurology, The Jikei University School of Medicine West Medical Center, Tokyo, Japan.
Tomomichi KitagawaDepartment of Neurology, The Jikei University School of Medicine West Medical Center, Tokyo, Japan.
Yuri Mizuno-ShojimaDepartment of Neurology, The Jikei University School of Medicine West Medical Center, Tokyo, Japan.
Hiroki TakatsuDepartment of Neurology, The Jikei University Katsushika Medical Center, Tokyo, Japan.
Teppei KomatsuDepartment of Neurology, The Jikei University School of Medicine, Tokyo, Japan.
Kenichi SakutaDepartment of Neurology, The Jikei University School of Medicine, Tokyo, Japan.
Hidetaka MitsumuraDepartment of Neurology, The Jikei University School of Medicine, Tokyo, Japan.
Yasuyuki IguchiDepartment of Neurology, The Jikei University School of Medicine, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSerum acylcarnitine-to-free carnitine (AC/FC) ratio has been proposed as an indicator of mitochondrial function and plays an important role in brain recovery. Although mitochondrial dysfunction promotes systemic inflammation and atherosclerosis, the prognostic value and pathophysiological implications of the AC/FC ratio in acute ischemic stroke (AIS) remain unclear. This study examined the association between the AC/FC ratio and prognosis as well as its relationship with systemic inflammation and atherosclerosis.

methodsWe enrolled consecutive patients with AIS admitted within 72 h of onset between October 2022 and November 2024. A favorable outcome was defined as a modified Rankin Scale score of 0-1 at 3 months. We determined the optimal AC/FC cutoff using receiver operating characteristic (ROC) analysis. Systemic inflammation and atherosclerosis were assessed using fibrinogen-to-albumin ratio (FAR) and ankle-brachial index (ABI).

resultsOf 463 screened patients, 285 were included (210 [74%] males; median age, 69 years), of whom 80 (28%) had unfavorable outcome. Poisson regression analysis with a robust variance estimator showed that an elevated AC/FC ratio was significantly associated with unfavorable outcome (PR 1.235, 95% CI 1.131-1.350, p < 0.001). Furthermore, higher FAR (PR 1.610, 95% CI 1.218-2.129, p = 0.001) and lower ABI (PR 0.268, 95% CI 0.099-0.727, p = 0.010) were associated with the AC/FC group above the optimal cutoff of 0.29 evaluated based on ROC analysis.

conclusionsAn elevated serum AC/FC ratio was independently associated with unfavorable functional outcome in AIS and correlated with markers of systemic inflammation and atherosclerosis.

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PMID42563006

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.