Evidence map›Paper›PMID 42563009›Full record

ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2026

Dissociable control of depression and visceral pain by the pIC

Miao-Miao Guo, Si-Ting Huang, Ru Jia, Mu Zhou, Feng-Xin Zhu, Yang Xu, Ying Song, Yong-Mei Zhang

Abstract read
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In one paragraph

Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Miao-Miao Guo *Jiangsu Province Key Laboratory of Anesthesioloy and Brain Science, Xuzhou Medical University, Xuzhou, China.
Si-Ting Huang *Jiangsu Province Key Laboratory of Anesthesioloy and Brain Science, Xuzhou Medical University, Xuzhou, China.
Ru JiaJiangsu Province Key Laboratory of Anesthesioloy and Brain Science, Xuzhou Medical University, Xuzhou, China.
Mu ZhouJiangsu Province Key Laboratory of Anesthesioloy and Brain Science, Xuzhou Medical University, Xuzhou, China.
Feng-Xin ZhuJiangsu Province Key Laboratory of Anesthesioloy and Brain Science, Xuzhou Medical University, Xuzhou, China.
Yang XuJiangsu Province Key Laboratory of Anesthesioloy and Brain Science, Xuzhou Medical University, Xuzhou, China.
Ying SongJiangsu Province Key Laboratory of Anesthesioloy and Brain Science, Xuzhou Medical University, Xuzhou, China.
Yong-Mei ZhangJiangsu Province Key Laboratory of Anesthesioloy and Brain Science, Xuzhou Medical University, Xuzhou, China. zhangym700@163.com.ORCID http://orcid.org/0000-0002-0919-904X

Funding

National Natural Science Foundation of China (National Science Foundation of China) No.82271257National Natural Science Foundation of China (National Science Foundation of China) No.82471244
6 · The paper itself

Abstract

Comorbid depressive symptoms are highly prevalent in patients with chronic colitis, posing a major clinical challenge because pain and depression often fail to respond to the same treatment. However, the neural mechanisms underlying this comorbidity remain poorly understood. Using a dextran sulfate sodium (DSS)-induced chronic colitis mouse model, we identified depression-resilient and depression-susceptible phenotypes and uncovered a critical role for the posterior insular cortex glutamatergic (pIC

Identifiers

PMID42563009

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.