Evidence map›Paper›PMID 42563031›Full record

ReviewNature neuroscience2026

Comparative insights into insula structure and function.

Joey A Charbonneau, Sarah B Carp, Jeffrey L Bennett, Savannah M Maw, Gilda Moadab, John P Christianson, Mark G Baxter, Eliza Bliss-Moreau

Abstract readReviewComparative Study
PubMed Publisher
In one paragraph

Review in Nature neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Joey A CharbonneauNational Biomedical Research Institute, University of California Davis, Davis, CA, USA. j.charbonneau@nyu.edu.ORCID http://orcid.org/0000-0003-4384-461X
Sarah B CarpNational Biomedical Research Institute, University of California Davis, Davis, CA, USA.
Jeffrey L BennettNational Biomedical Research Institute, University of California Davis, Davis, CA, USA.ORCID http://orcid.org/0000-0002-3255-5663
Savannah M MawNational Biomedical Research Institute, University of California Davis, Davis, CA, USA.
Gilda MoadabNational Biomedical Research Institute, University of California Davis, Davis, CA, USA.
John P ChristiansonDepartment of Psychology and Neuroscience, Boston College, Chestnut Hill, MA, USA.
Mark G BaxterSection on Comparative Medicine, Department of Pathology, Wake Forest University School of Medicine, Winston-Salem, NC, USA.ORCID http://orcid.org/0000-0002-8907-0923
Eliza Bliss-MoreauNational Biomedical Research Institute, University of California Davis, Davis, CA, USA. eblissmoreau@ucdavis.edu.ORCID http://orcid.org/0000-0002-0740-5612

Funding

An animal model of early Alzheimer’s disease pathogenesis in the interoceptive-allostatic networkRF1AG078340 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BLISS-MOREAU, ELIZA · 2022 to 2025
$3.9M
Insula Structure and Function in a Nonhuman Primate Model of Induced Early Alzheimer's DiseaseF31AG077797 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHARBONNEAU, JOSEPH · 2022 to 2023
$80k
U.S. Department of Health & Human Services | National Institutes of Health (NIH) F31AG077797U.S. Department of Health & Human Services | National Institutes of Health (NIH) RF1 AG078340
6 · The paper itself

Abstract

The insular cortex has become an increasingly important focus of neuroscientific research because of its broad involvement in psychological and behavioral processes and its dysfunction in neuropsychiatric, developmental, degenerative and metabolic disorders. The insula is easily imaged in the human brain and is also a key target for both fundamental and translational studies in nonhuman animals. However, owing to a dearth of truly comparative studies on the insula, the extent to which this region shares structural and functional homologies between humans, monkeys and rodents remains incompletely understood. Here, we systematically evaluate current knowledge regarding homologies in the insula among model species and humans. We examine the strengths and limitations of various laboratory species for investigating the insula, and discuss how these factors influence the interpretation of findings and their application to the human insula. Finally, we propose research directions aimed at strengthening translational insula research and enhancing our understanding of cross-species similarities and differences.

Indexed as

Cerebral CortexInsular CortexAnimalsBrain MappingHumansSpecies Specificity

Identifiers

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.