Evidence map›Paper›PMID 42563161›Full record

ArticleCell communication and signaling : CCS2026

Tissue-stiffness-driven platelet activation emerges as a potential target for breast cancer prevention and treatment.

Menikae K Heenkenda, Xingyue Wang, Wen Zhong, Annelie Abrahamsson, Nina Reustle, Daniel Aili, Peter Lundberg, Tomas L Lindahl, Charlotta Dabrosin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell communication and signaling : CCS, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Menikae K HeenkendaDepartment of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
Xingyue WangDepartment of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
Wen ZhongDepartment of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
Annelie AbrahamssonDepartment of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
Nina ReustleDivision of Biophysics and Bioengineering, Department of Physics, Chemistry and Biology, Laboratory of Molecular Materials, Linköping University, Linköping, Sweden.
Daniel AiliDivision of Biophysics and Bioengineering, Department of Physics, Chemistry and Biology, Laboratory of Molecular Materials, Linköping University, Linköping, Sweden.
Peter LundbergClinical Department of Medical Radiation Physics, Region Östergötland, Linköping, Sweden.
Tomas L LindahlDepartment of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
Charlotta DabrosinDepartment of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden. charlotta.dabrosin@liu.se.ORCID http://orcid.org/0000-0001-7191-0018

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHigh mammographic breast density is a strong independent risk factor for sporadic breast cancer, yet involved mechanisms remain poorly defined. The extracellular compartment plays a critical role in the intercellular communication during tumor initiation and progression. Although several mechanosensitive pathways have been described, the role of platelets (PLTs) in stiffness-driven signaling in the breast is unknown.

methodsExtracellular soluble proteins were sampled in situ from live breast tissue using microdialysis. A total of 108 postmenopausal women were included: women with nondense or dense breasts, women with dense breasts randomized to low-dose acetylsalicylic acid (ASA; 160 mg/day) or no treatment, and patients with estrogen receptor-positive (ER

resultsDense breast tissue exhibited a distinct extracellular proteomic signature enriched for proteins associated with platelet activation, along with alterations in several immunomodulatory pathways. Several PLT-associated proteins were also elevated in ER

conclusionsTissue stiffness is a critical regulator of PLT mechanotransduction in dense breast tissue, contributing to a microenvironment permissive for cancer progression. These findings highlight PLT mechanobiology as a potential target for breast cancer prevention and therapy. CLINICAL

trial registrationEudraCT: 2017-000317-22.

Indexed as

Breast NeoplasmsPlatelet ActivationAspirinBlood PlateletsBreast DensityFemaleHumansMiddle AgedProteomicsAspirinBreast microenvironmentExtracellular signalingMammographic densityMechanotransductionMicrodialysisPlatelets

Identifiers

PMID42563161
PMCPMC13445922

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.