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ArticleNeurological research and practice2026

Mental health and suicidality in glioblastoma patients in germany - a multicenter cross-sectional observational study protocol (SHINE-GLIO Study).

Mareike Rutenkröger, Maximilian Scheer, Niklas Benedikt Pepper, Felix Ehret, Franziska M Ippen, Teresa Schmidt, Jana Grieger, Giorgio Cappello, Leon Jekel, Lazaros Lazaridis and 10 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurological research and practice, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07409584 (Mental Health and Suicidality in Glioblastoma Patients in Germany - a Multicenter Observational Study), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07409584 recruitingnot on this map

Mental Health and Suicidality in Glioblastoma Patients in Germany - a Multicenter Observational Study (SHINE-GLIO Study)

TypeobservationalSponsorUniversity Hospital, EssenRan2026 to 2028Enrolled180ConditionsGlioblastoma (GBM)ArmsMedical history, physical examination, completing questionnaires, data collection
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Mareike RutenkrögerDepartment of Medical Psychology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID http://orcid.org/0000-0002-2122-6661
Maximilian ScheerDepartment of Neurosurgery, University Hospital Heidelberg, Heidelberg, Germany.
Niklas Benedikt PepperDepartment of Radiation Oncology, University Hospital Muenster, Muenster, Germany.
Felix EhretDepartment of Radiation Oncology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, Berlin, Germany.ORCID http://orcid.org/0000-0001-6177-1755
Franziska M IppenDepartment of Neurology, University Hospital Heidelberg, Heidelberg, Germany.
Teresa SchmidtDepartment of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), Division of Clinical Neuro-Oncology, University Medicine Essen, University of Duisburg-Essen, Essen, Germany.
Jana GriegerDepartment of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), Division of Clinical Neuro-Oncology, University Medicine Essen, University of Duisburg-Essen, Essen, Germany.
Giorgio CappelloDepartment of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), Division of Clinical Neuro-Oncology, University Medicine Essen, University of Duisburg-Essen, Essen, Germany.
Leon JekelDepartment of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), Division of Clinical Neuro-Oncology, University Medicine Essen, University of Duisburg-Essen, Essen, Germany.
Lazaros LazaridisDepartment of Neurology, University Hospital Knappschaftskrankenhaus Bochum, Ruhr University Bochum, Bochum, Germany.
Ulrich SureDepartment of Neurosurgery and Spine Surgery and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), University Medicine Essen, University of Duisburg-Essen, Essen, Germany.
Laurèl RauschenbachDepartment of Neurosurgery and Spine Surgery and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), University Medicine Essen, University of Duisburg-Essen, Essen, Germany.
Yahya AhmadipourDepartment of Neurosurgery and Spine Surgery and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), University Medicine Essen, University of Duisburg-Essen, Essen, Germany.
Christoph KleinschnitzDepartment of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), Division of Clinical Neuro-Oncology, University Medicine Essen, University of Duisburg-Essen, Essen, Germany.
Lasse DührsenDepartment of Neurosurgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Joachim Peter SteinbachDr. Senckenberg Institute of Neurooncology, University Hospital, Goethe University, Frankfurt, Frankfurt, Germany.
Heidrun GollaDepartment of Palliative Medicine, University Medical Center Göttingen, Göttingen, Germany.
Corinna Seliger-BehmeDepartment of Neurology, University Hospital Knappschaftskrankenhaus Bochum, Ruhr University Bochum, Bochum, Germany.
Christoph Oster *Department of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), Division of Clinical Neuro-Oncology, University Medicine Essen, University of Duisburg-Essen, Essen, Germany.ORCID http://orcid.org/0000-0002-0683-0430
Sied Kebir *Department of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), Division of Clinical Neuro-Oncology, University Medicine Essen, University of Duisburg-Essen, Essen, Germany. sied.kebir@uk-essen.de.ORCID http://orcid.org/0000-0002-0678-5852

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionGlioblastoma is an aggressive primary brain tumor with poor survival. Depressive and anxiety symptoms and suicidality are common and impair quality of life and care. Prospective multicenter data using validated measures of suicidal ideation and behavior in German glioblastoma cohorts are scarce. We aim to quantify psychiatric symptom burden and suicidality and examine associations with demographic, clinical, and tumor-related characteristics.

methodsSHINE-GLIO is a multicenter, cross-sectional observational study at German neuro-oncology centers. Adults with newly diagnosed isocitrate dehydrogenase wild-type glioblastoma after primary radiotherapy and before first recurrence are eligible. Exclusion criteria include clinically significant aphasia, other malignancies, and known tumor predisposition syndromes. At one outpatient visit, participants undergo physical examination and complete validated self-report questionnaires assessing suicidality (SSEV), depressive symptoms (PHQ-8), anxiety (GAD-7), social support (SUCE-4), and quality of life (EORTC QLQ-C30 and QLQ-BN20). Tumor characteristics, clinical history, and concomitant medications are extracted from medical records. Prespecified regression models will examine associations with suicidality while accounting for demographic, clinical, and tumor-related factors. PERSPECTIVE: This study will provide a standardized multicenter assessment of suicidality and related psychiatric symptoms in German patients with glioblastoma. The findings may inform screening and referral pathways for mental health care.

trial registrationClinicalTrials.gov identifier: NCT07409584. First posted prospectively on February 12, 2026.

Indexed as

AnxietyDepressionGermanyGlioblastomaPatient-reported outcomesSuicidality

Identifiers

PMID42563203
PMCPMC13449389

What Socratic holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.