Age-stratified clinical characteristics and long-term neurological outcomes of pediatric herpes simplex virus encephalitis: a longitudinal cohort study of 56 children.

Background and objective: Age-specific clinical characteristics and prognostic predictors of pediatric herpes simplex virus encephalitis (HSE) remain incompletely characterized. This study aimed to characterize age-dependent manifestations and identify factors independently associated with poor long-term outcomes. Methods: A longitudinal cohort study included 56 pediatric patients with confirmed HSE who were admitted to the Children's Hospital Affiliated to Zhengzhou University from January 2018 to June 2023. Patients were stratified into three age groups: infant/toddler group (0-3 years), preschool group (3-6 years), and school-age and older group (6-18 years). Clinical, laboratory, and cranial magnetic resonance imaging (MRI) data were collected. Neurological outcomes were assessed using the pediatric modified Rankin Scale (mRS). Multivariate logistic regression analysis was performed to identify independent associated factors of poor prognosis. Results: The median age of onset was 2.09 years, and 60.7% of patients were aged under 3 years. Unilateral facial and/or perioral twitching occurred in 33.9% of patients, all of whom under 5 years of age, with the highest incidence in the preschool group (70.0%, Conclusion: Pediatric HSE exhibits notable age-associated heterogeneity. A low acute GCS score and prolonged seizure duration were identified as independent associated factors for poor prognosis in this exploratory analysis, whereas early facial/perioral twitching was associated with subsequent language sequelae. The risk of anti-NMDAR encephalitis increases with age, necessitating long-term surveillance. These age-stratified findings are descriptive and hypothesis-generating and require confirmation in larger prospective cohorts.