Evidence mapPaperPMID 42564296Full record

ReviewFrontiers in cell and developmental biology2026

Adipose tissue for reconstruction and wound healing: applications, challenges, and future directions.

Karolina Kondej, Paulina Słonimska, Aneta Skoniecka, Agata Tymińska, Agnes S Klar, Michał Pikuła

Abstract readReview
In one paragraph

Review in Frontiers in cell and developmental biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Karolina KondejDepartment of Surgery and Urology for Children and Adolescents, Medical University of Gdansk, Gdańsk, Poland.
Paulina SłonimskaDepartment of Clinical Anatomy, Medical University of Gdansk, Gdańsk, Poland.
Aneta SkonieckaLaboratory of Tissue Engineering and Regenerative Medicine, Division of Embryology, Medical University of Gdansk, Gdańsk, Poland.
Agata TymińskaLaboratory of Tissue Engineering and Regenerative Medicine, Division of Embryology, Medical University of Gdansk, Gdańsk, Poland.
Agnes S KlarTissue Biology Research Unit, University Children's Hospital Zurich, Zurich, Switzerland.
Michał PikułaLaboratory of Tissue Engineering and Regenerative Medicine, Division of Embryology, Medical University of Gdansk, Gdańsk, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adipose tissue has emerged as an important therapeutic resource in regenerative medicine due to its accessibility and its rich content of regenerative cells and bioactive factors. Adipose-derived products, including lipoaspirate, stromal vascular fraction (SVF), and adipose-derived mesenchymal stromal/stem cells (AD-MSCs), are increasingly used in clinical practice for tissue reconstruction, wound healing, and the treatment of complex tissue defects. In this review, we summarize current clinical applications of adipose tissue-based therapies, focusing on their role in tissue regeneration and wound management. We briefly discuss adipose tissue harvesting techniques and the biological characteristics of AD-MSCs relevant to their therapeutic use. Attention is given to clinical evidence regarding efficacy, safety, and translational challenges associated with SVF- and AD-MSC-based interventions. We highlight current limitations and future directions for the integration of adipose tissue-derived therapies into regenerative and reconstructive medicine.

Indexed as

adipose-derived stem cellsfat/adipose tissueregenerative medicinestem cellsstromal vascular fraction

Identifiers

PMID42564296
PMCPMC13442683

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.