ArticleAfrican journal of laboratory medicine2026
Expression of p53 and p63 proteins and their correlation with histological grades among gastric carcinoma specimens at Mbarara Regional Referral Hospital.
Article in African journal of laboratory medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Gastric carcinoma remains one of the most common and deadly cancers worldwide, especially among older men. In sub-Saharan Africa and Uganda in particular, the diagnostic biomarkers of gastric carcinomas are not well documented; also, limited studies have been conducted in Uganda regarding the prognostic and diagnostic value of p53 and p63 immunohistochemical expression in gastric carcinomas. Objective: We aimed to determine the immunohistochemical expression of p53 and p63 proteins and their correlation with different histological grades among archived gastric carcinoma specimens at Mbarara Regional Referral Hospital. Methods: This was a laboratory-based cross-sectional study. We retrieved 166 archived formalin-fixed paraffin-embedded gastric carcinoma tissue specimens from the histopathology laboratory. They were stained with Harris haematoxylin and eosin stain and subsequently stained with p63 and p53 monoclonal antibody immunohistochemistry. Results: Of the 166 gastric carcinoma specimens retrieved, almost a third of specimens were poorly differentiated (53/166; 32%) although the majority were moderately differentiated (68/166; 41%). P53 expression was 20/45 (44.4%), 27/68 (39.7) and 21/53 (39.6) in well-differentiated, moderately differentiated and poorly differentiated gastric carcinoma. Statistically significant positive correlation was observed between p63 and weak immunohistochemical expression (Spearman rho 0.155, Conclusion: P53 expression was more than p63 expression in different histological grades. There was no significant correlation of p53 with different histological grades but significant correlation was observed between p63 and moderately differentiated gastric carcinoma specimens. We recommend a prospective study using advanced molecular tests on fresh gastric carcinoma specimens to assess the prognostic usefulness of p53 and p63 biomarkers. What this study adds: This study provides the first Ugandan data on p53 and p63 expression in gastric carcinoma, highlighting p63's significant correlation with moderately differentiated tumours.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.