Outcomes of Surgical Versus Conservative Management in Severe Traumatic Brain Injury (GCS 3-4) With Evacuable Mass Lesions: A Retrospective Cohort Study.

Objective: Management of patients with severe traumatic brain injury (TBI) presenting with Glasgow Coma Scale (GCS) scores of 3-4 and surgically evacuable intracranial hematomas remains controversial because of perceived futility and poor outcomes. This study compared outcomes of surgical versus conservative management in this patient population. Methods: This retrospective observational study included patients with TBI (GCS 3-4) and surgically evacuable intracranial mass lesions admitted to a tertiary care centre between December 2015 and December 2023. Among 3,657 TBI admissions, 752 patients met inclusion criteria: 568 underwent surgical management and 184 were treated conservatively. Clinical and radiological variables were analysed. Outcomes were assessed at 6 months using the Glasgow Outcome Scale (GOS). Favorable outcome was defined as GOS 3-5, given the high mortality in this cohort. Subgroup analysis and multivariable logistic regression analysis were performed. Results: Six-month mortality was significantly lower in the surgical group (79.2% vs. 94.5%). Surgery was associated with shorter intensive care unit stay ( Conclusion: Despite an overall poor prognosis, surgical evacuation of mass lesions in TBI patients with GCS 3-4 was associated with improved survival and functional outcomes in selected patients, although causality cannot be inferred.