ArticleEnvironmental health perspectives2026
Multibehavioral Phenotyping in Early-Life-Stage Zebrafish for Identifying Disruptors of Nonassociative Learning.
Article in Environmental health perspectives, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundThe vertebrate nervous system is vulnerable to chemical toxicity, and the widespread release of chemicals into the environment outstrips the capacity to assess their safety. The zebrafish (
objectiveWe sought to establish a multibehavioral phenotyping approach in larval zebrafish to identify and mechanistically elucidate neuroactive chemicals, with particular focus on chemical compounds that affect nonassociative habituation learning.
methodsWe devised a battery of automated behavioral assays in larval zebrafish. The battery captures stereotypical visual and acoustic behaviors including habituation, a form of nonassociative learning. To elucidate mechanisms underlying exposure-induced behavioral alterations in zebrafish,
resultsKnown pharmacological modulators of habituation in zebrafish evoked distinct behavioral patterns. By screening chemicals positive for
conclusionsThese studies combined a series of behavior assays in a phenotypically rich, rapid, and inexpensive nonmammalian vertebrate test system to screen chemicals for neurotoxicity. Together with
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