Evidence map›Paper›PMID 42564813›Full record

ArticleInternational journal of hepatology2026

Impact of Obeticholic Acid Therapy on Insulin Resistance and Metabolic Parameters in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD).

Majid Almansouri, Hani Shalabi, Mohammed Karami, Omar Alharthy, Ali Kabli, Mohammad Khalil, Maan Alkhattabi, Dahlia Mirdad, Ahmed Alharthy, Ahmed Abduljabbar and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of hepatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Majid AlmansouriDepartment of Clinical Biochemistry, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia, kau.edu.sa.ORCID https://orcid.org/0009-0002-0443-8002
Hani ShalabiDepartment of Internal Medicine, Faculty of Medicine, University of Jeddah, Jeddah, Saudi Arabia, uj.edu.sa.ORCID https://orcid.org/0009-0005-4268-0408
Mohammed KaramiDepartment of Clinical Physiology, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia, kau.edu.sa.ORCID https://orcid.org/0000-0002-8943-0626
Omar AlharthyDepartment of Internal Medicine, Faculty of Medicine, University of Taibah, Madina, Saudi Arabia, taibahu.edu.sa.
Ali KabliDepartment of Physiology, Faculty of Medicine, King Abdulaziz University, Rabigh, Saudi Arabia, kau.edu.sa.ORCID https://orcid.org/0009-0001-6804-163X
Mohammad KhalilDepartment of Radiology, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia, kau.edu.sa.ORCID https://orcid.org/0000-0002-5188-9626
Maan AlkhattabiDepartment of Internal Medicine, Faculty of Medicine, King Abdulaziz University, Rabigh, Saudi Arabia, kau.edu.sa.ORCID https://orcid.org/0000-0002-9817-1144
Dahlia MirdadDepartment of Basic Medical Sciences, Faculty of Medicine, University of Jeddah, Jeddah, Saudi Arabia, uj.edu.sa.ORCID https://orcid.org/0009-0003-9931-4850
Ahmed AlharthyDepartment of Radiology, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia, kau.edu.sa.ORCID https://orcid.org/0000-0002-2276-7988
Ahmed AbduljabbarDepartment of Radiology, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia, kau.edu.sa.ORCID https://orcid.org/0000-0003-0508-8657
Mohammed WazzanDepartment of Radiology, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia, kau.edu.sa.ORCID https://orcid.org/0000-0003-1950-3962
Hatim AlabsiDepartment of Radiology, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia, kau.edu.sa.
Siti S MaidinDepartment of Data Science, INTI International University, Nilai, Malaysia, newinti.edu.my.ORCID https://orcid.org/0000-0003-0714-2186
Humaira WaseemDepartment of Data Science, INTI International University, Nilai, Malaysia, newinti.edu.my.ORCID https://orcid.org/0000-0002-2479-2247
Amber HassanDepartment of Neurogenetics, Istituto Neurologico Nazionale a Carattere Scientifico, IRCCS, Pavia, Italy, ircc.it.ORCID https://orcid.org/0000-0001-9362-0935

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a common metabolic liver condition primarily managed through lifestyle modification. Obeticholic acid (OCA), a farnesoid X receptor agonist, has shown therapeutic benefits in steatohepatitis, yet its short-term metabolic effects remain unclear. This study compared OCA plus lifestyle modification versus lifestyle intervention alone in adults with MASLD. Methods: This quasi-experimental study included 360 adults aged 18-60 years with ultrasound-diagnosed MASLD and insulin resistance (HOMA - IR > 2.0). Patients with diabetes mellitus, viral hepatitis, cirrhosis, advanced fibrosis, ischemic heart disease or LDL - C > 160 mg/dL were excluded. Participants received either OCA (10 mg/day) plus standardised lifestyle modification or lifestyle intervention alone for 3 months. Anthropometric, biochemical and hepatic parameters were evaluated at baseline and follow-up, with ANCOVA performed to adjust for baseline covariates. Results: Baseline demographic and metabolic characteristics were comparable between groups. After 3 months, the OCA plus lifestyle group demonstrated significantly greater improvements in ALT (36.65 ± 20.57 vs. 48.19 ± 21.35 U/L; Conclusion: Over 3 months, OCA combined with lifestyle modification improved liver enzymes, steatosis and fibrosis-related surrogate indices, and modestly reduced insulin resistance. Careful lipid monitoring is recommended, and longer term studies are required to clarify the overall metabolic and cardiovascular implications.

Indexed as

insulin resistancemetabolic dysfunction–associated steatotic liver diseaseobeticholic acid

Identifiers

PMID42564813
PMCPMC13446147

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.