Evidence map›Paper›PMID 42564816›Full record

ArticleReaction kinetics, mechanisms and catalysis2026

Octahedral [(8-quinolinyl/phenanthridinyl)amine)Ga(III)] complexes, reactivity, affinity for biomolecules, anti-cancer and computational evaluations.

Phakamani C Dlamini, Thato T Medupe, Lucy W Macharia, Karabo Serala, Sharon Prince, Gregory S Smith, Irvin N Booysen, Allen Mambanda

Abstract read
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In one paragraph

Article in Reaction kinetics, mechanisms and catalysis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Phakamani C DlaminiSchool of Agriculture and Science, University of KwaZulu-Natal, Private Bag X01, Scottsville, Pietermaritzburg, 3209 South Africa.
Thato T MedupeDepartment of Chemistry, University of Cape Town, Private Bag X3, Rondebosch, 7701 South Africa.
Lucy W MachariaDepartment of Human Biology, Faculty of Health Science, Observatory, University of Cape Town, Cape Town, 7925 South Africa.
Karabo SeralaDepartment of Human Biology, Faculty of Health Science, Observatory, University of Cape Town, Cape Town, 7925 South Africa.
Sharon PrinceDepartment of Human Biology, Faculty of Health Science, Observatory, University of Cape Town, Cape Town, 7925 South Africa.
Gregory S SmithDepartment of Chemistry, University of Cape Town, Private Bag X3, Rondebosch, 7701 South Africa.
Irvin N BooysenSchool of Agriculture and Science, University of KwaZulu-Natal, Private Bag X01, Scottsville, Pietermaritzburg, 3209 South Africa.
Allen MambandaSchool of Agriculture and Science, University of KwaZulu-Natal, Private Bag X01, Scottsville, Pietermaritzburg, 3209 South Africa.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Octahedral iodo gallium(III) complexes, GaL1-L3(SN)I, incorporating bis-(azaaryl)amine ligands (L1-L3) with varying conformational flexibility, were synthesized and characterized by spectroscopic and elemental analyses to evaluate ligand effects on reactivity and affinity for biological targets. Iodide substitution by biologically relevant nucleophiles (guanine and thiourea), monitored spectrophotometrically, revealed ligand-dependent rates, with the fastest substitution observed for the dicationic GaL1(SN)I bearing the most compact and flexible ligand (L1), compared to the more rigid monocationic L2 and L3 analogues. UV-Visible studies of interactions with bovine serum albumin and calf thymus DNA indicated moderate to strong binding ( Supplementary Information: The online version contains supplementary material available at 10.1007/s11144-026-03129-6.

Indexed as

Anticancer cytotoxicityDNA/BSA interactionsGa(III) complexesMolecular dockingSubstitution kinetics

Identifiers

PMID42564816
PMCPMC13446110

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.