Evidence map›Paper›PMID 42565002›Full record

ArticleBioactive materials2026

Metabolism of citrate-mediated PI3K-Akt signaling and primary cilium regulates spatiotemporal craniofacial mineralization.

Jiaying Zhao, Sijia Hao, Ning Gao, Hao Zhang, Yiqian Yu, Yani Chen, Bicong Gao, Junhong Lai, Zhikang Wang, Zili Gao and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Jiaying ZhaoStomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Zhejiang Key Laboratory of Oral Biomedical, Hangzhou, 310000, PR China.
Sijia HaoStomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Zhejiang Key Laboratory of Oral Biomedical, Hangzhou, 310000, PR China.
Ning GaoStomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Zhejiang Key Laboratory of Oral Biomedical, Hangzhou, 310000, PR China.
Hao ZhangDepartment of Materials Science and Engineering, Westlake University, Hangzhou, Zhejiang, 310030, PR China.
Yiqian YuState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan, 430079, PR China.
Yani ChenStomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Zhejiang Key Laboratory of Oral Biomedical, Hangzhou, 310000, PR China.
Bicong GaoStomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Zhejiang Key Laboratory of Oral Biomedical, Hangzhou, 310000, PR China.
Junhong LaiStomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Zhejiang Key Laboratory of Oral Biomedical, Hangzhou, 310000, PR China.
Zhikang WangStomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Zhejiang Key Laboratory of Oral Biomedical, Hangzhou, 310000, PR China.
Zili GaoDepartment of Materials Science and Engineering, Westlake University, Hangzhou, Zhejiang, 310030, PR China.
Yueqi NiState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan, 430079, PR China.
Jinglun ZhangDepartment of Orthodontics, Nanjing Stomatological Hospital, Affiliated Hospital of Medical School, Institute of Stomatology, Nanjing University, 30 Zhongyang Road, Nanjing, Jiangsu, 210008, PR China.
Lujiao ZhangDepartment of Materials Science and Engineering, Westlake University, Hangzhou, Zhejiang, 310030, PR China.
Wenjin CaiStomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Zhejiang Key Laboratory of Oral Biomedical, Hangzhou, 310000, PR China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The repair of craniofacial bones requires high-quality mineralization. The key regulator involved in the difference in mineralization of craniofacial bones remains unknown. As the main component of the bone, citrate regulates hydroxyapatite crystallization. We found that the regional accumulation of citrate caused differences in mineralization. Transcriptome analysis showed that the expression of the PI3K-Akt signaling pathway and primary cilia was significantly different between mineralized and unmineralized areas. Citrate specifically activated the PI3K-Akt signaling pathway to form a positive feedback loop and strengthened the metabolic activity of osteoblasts. The cooperation between citrate and primary cilia improved osteogenesis and stabilized the structure of amorphous calcium phosphate clusters. Our research reveals a new citrate-mediated metabolic-signaling-structure pattern. It explains the regional differences in mineralization of craniofacial bones and offers a theoretical basis for bone development mechanisms and regeneration strategies.

Indexed as

CitrateCraniofacial boneMetabolic regulationMineralizationPI3K-Akt signaling pathwayPrimary cilia

Identifiers

PMID42565002
PMCPMC13445505

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.