Evidence map›Paper›PMID 42565101›Full record

ArticlePain reports2026

Randomized trial of intraoperative nitrous oxide for postoperative pain reduction in cervical spinal cord injury.

Mayu Hoshina, Takao Kato, Yuki Shiko, Yohei Kawasaki, Kunihide Okubo, Akiko Kimura, Madoka Yokotani, Yusuke Mazda, Tadashi Yahata, Koichi Inokuchi and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pain reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Mayu HoshinaDepartment of Anesthesiology, Saitama Medical Center, Saitama Medical University, Kawagoe, Japan.ORCID https://orcid.org/0009-0008-4434-9585
Takao KatoDepartment of Anesthesiology, Saitama Medical Center, Saitama Medical University, Kawagoe, Japan.
Yuki ShikoDepartment of Biostatistics, Graduate School of Medicine, Saitama Medical University, Moroyama, Japan.
Yohei KawasakiDepartment of Biostatistics, Graduate School of Medicine, Saitama Medical University, Moroyama, Japan.
Kunihide OkuboDepartment of Anesthesiology, Saitama Medical Center, Saitama Medical University, Kawagoe, Japan.
Akiko KimuraDepartment of Anesthesiology, Saitama Medical Center, Saitama Medical University, Kawagoe, Japan.
Madoka YokotaniDepartment of Anesthesiology, Saitama Medical Center, Saitama Medical University, Kawagoe, Japan.
Yusuke MazdaDepartment of Obstetric Anesthesiology, Center for Maternal-Fetal and Neonatal Medicine, Saitama Medical Center, Saitama Medical University, Kawagoe, Japan.
Tadashi YahataAdvanced Center for Emergency and Critical Care Medicine, Saitama Medical Center, Saitama Medical University, Kawagoe, Japan.
Koichi InokuchiAdvanced Center for Emergency and Critical Care Medicine, Saitama Medical Center, Saitama Medical University, Kawagoe, Japan.
Hideaki ObataDepartment of Anesthesiology, Saitama Medical Center, Saitama Medical University, Kawagoe, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Neuropathic pain after cervical spinal cord injury (SCI) is common and difficult to manage. Objectives: To evaluate whether intraoperative nitrous oxide (N Methods: This single-center, randomized study enrolled adults (≥20 yr) undergoing emergency surgery for traumatic cervical SCI (American Spinal Injury Association Impairment Scale C or D). Patients were randomly assigned to receive intraoperative N Results: Of 80 randomized patients, 59 were analyzed (mean [SD] age 70.34 [12.07] years; 46 [78%] male). Baseline characteristics were similar between groups (Air, n = 29; N Conclusion: Intraoperative N

Indexed as

Central sensitizationCervical spinal cord injuryNeuropathic painNitrous oxidePostoperative painRandomized clinical trial

Identifiers

PMID42565101
PMCPMC13446972

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.