Evidence map›Paper›PMID 42565473›Full record

ArticleEmerging microbes & infections2026

A rapid detection of Nipah virus nucleocapsid antigen in inactivated viral cultures.

Gyeongmu Choi, Jung Kim, Hansaem Lee, Pyeonghwa Jeon, Jae Hun Jeong, Yujin Jung, Jin Seo Park, Mi Kyoung Lee, Kyung-Chang Kim, Joo-Yeon Lee and 8 more

Abstract read
In one paragraph

Article in Emerging microbes & infections, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Gyeongmu ChoiCenter for Infectious Disease Vaccine and Diagnosis Innovation, Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea.
Jung KimCenter for Infectious Disease Vaccine and Diagnosis Innovation, Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea.
Hansaem LeeDivision of Emerging Virus & Vector Research, Center for Emerging Virus Research, Cheongju, Republic of Korea.
Pyeonghwa JeonDivision of Emerging Virus & Vector Research, Center for Emerging Virus Research, Cheongju, Republic of Korea.
Jae Hun JeongDivision of Emerging Virus & Vector Research, Center for Emerging Virus Research, Cheongju, Republic of Korea.
Yujin JungCenter for Infectious Disease Vaccine and Diagnosis Innovation, Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea.
Jin Seo ParkCenter for Infectious Disease Vaccine and Diagnosis Innovation, Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea.
Mi Kyoung LeeCenter for Infectious Disease Vaccine and Diagnosis Innovation, Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea.
Kyung-Chang KimDivision of Emerging Virus & Vector Research, Center for Emerging Virus Research, Cheongju, Republic of Korea.
Joo-Yeon LeeCenter for Emerging Virus Research, Korea National Institute of Health, Korea Disease Control and Prevention Agency, Cheongju, Republic of Korea.
Ha Yeon ParkCenter for Infectious Disease Vaccine and Diagnosis Innovation, Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea.
Changwoo ParkBiometrology Group, Korea Research Institute of Standards and Science, Daejeon, Republic of Korea.
Seil KimBiometrology Group, Korea Research Institute of Standards and Science, Daejeon, Republic of Korea.
Hana YiSchool of Biosystems and Biomedical Sciences, Korea University, Seoul, Republic of Korea.
Jihwan SongDepartment of Mechanical Engineering, Sogang University, Seoul, Republic of Korea.
Hyun-Joo KimDivision of Emerging Virus & Vector Research, Center for Emerging Virus Research, Cheongju, Republic of Korea.
Jong-Hwan LeeDepartment of Bionano Engineering, Hanyang University, Ansan, Republic of Korea.
Hong Gi KimCenter for Infectious Disease Vaccine and Diagnosis Innovation, Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nipah virus (NiV) is a highly lethal zoonotic henipavirus that causes severe respiratory disease and encephalitis and remains a priority pathogen for outbreak preparedness. Timely diagnosis is essential for containment, yet nucleic acid-based testing is often impractical in outbreak-prone, resource-limited settings. Here, we report the development of a rapid antigen test for NiV based on a cellulose nanobead (CNB)-enhanced lateral flow immunoassay (LFIA) targeting the viral nucleocapsid protein (NP). Anti-NiV NP antibodies were isolated from human synthetic phage-display libraries (scFv and Fab) by iterative bio-panning, reformatted as full-length IgGs, and screened using ELISA and immunofluorescence assays. Four lead antibodies were advanced to a sandwich-pairing matrix, which identified an optimized capture-detection configuration (mAb #5 as capture; mAb #2 as detection). Bio-layer interferometry confirmed nanomolar binding affinities for the selected antibodies (K

Indexed as

Antigens, ViralHenipavirus InfectionsNipah VirusNucleocapsid ProteinsAnimalsAntibodies, MonoclonalAntibodies, ViralEnzyme-Linked Immunosorbent AssayHumansImmunoassayRapid Diagnostic TestsVirus CultivationAntibodies, MonoclonalAntibodies, ViralAntigens, ViralNucleocapsid Proteinslateral flow immunoassayNipah virusnucleocapsidphage displaypoint-of-care diagnostics

Identifiers

PMID42565473
PMCPMC13508541

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.