ArticleAngewandte Chemie (International ed. in English)2026
Atypical Condensation Domains Guide Discovery and Illuminate Biosynthesis of Myxoglucamides Featuring Vinyl-Substituted, α-Oxidized γ-Amino Acids.
Article in Angewandte Chemie (International ed. in English), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Synthesis and Activity-Based Protein Profiling Identifies Aldo-Keto Reductase 1C3 as Target Protein of Myxoglucamides.Angewandte Chemie (International ed. in English) · 2026Article
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Authors and funding
11 authors.
Funding
Abstract
Condensation (C) domains in nonribosomal peptide synthetase (NRPS) pathways exhibit versatile functions that drive biosynthetic and chemical novelty. Through genome mining for atypical C domains, we identified a hybrid NRPS/polyketide synthase (PKS) biosynthetic gene cluster (mxg) from Cystobacterineae sp. MCy9003 and discovered myxoglucamides, a family of glycolipopeptides featuring an unprecedented vinyl-substituted γ-amino acid bearing an α-hydroxy/α-ketoamide functionality. Heterologous expression of the promoter-refactored pathway revealed new O-acylated myxoglucamides, and subsequent studies unveiled the C domain-like enzyme MxgH as a promiscuous O-acyltransferase decorating the glucose moiety with short-chain acyl groups. Biosynthetic investigations demonstrated that the unusual γ-amino acid originates from l-glutamate. Completion of the cryptic β-hydroxylation of peptidyl carrier protein-tethered glutamate by the α-ketoglutarate-dependent dioxygenase Ox
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