ArticleAnalytical and bioanalytical chemistry2026
Combination of antibody-based screening methods for the identification and quantification of Legionella pneumophila in process water.
Article in Analytical and bioanalytical chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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9 authors.
Funding
Abstract
Legionnaires' disease is a severe and often fatal pneumonia primarily caused by the inhalation of aerosols contaminated with the waterborne pathogen Legionella pneumophila serogroup 1. While conventional culture-based detection is often standard for monitoring evaporative cooling systems, the required 10-day cultivation period delays necessary risk assessments. To overcome this time barrier, we applied a novel approach to the flow-based chemiluminescence sandwich microarray immunoassay using cryopreserved Legionella pneumophila standards for rapid and culture-independent serotyping. The microarray features nine monoclonal and one polyclonal capture antibodies and successfully characterized the highly virulent Pontiac group at a concentration down to 10
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