Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
18 authors.
Zhengcai MaEngineering Research Center of Coptis Development and Utilization (Ministry of Education), School of Life Sciences, Southwest University, Chongqing 400715, China.ORCID 0009-0001-5611-9284
Juan LiEngineering Research Center of Coptis Development and Utilization (Ministry of Education), College of Pharmaceutical Sciences, Southwest University, Chongqing, 400715, China.ORCID 0009-0007-2371-3301
Xiaoduo LiEngineering Research Center of Coptis Development and Utilization (Ministry of Education), School of Life Sciences, Southwest University, Chongqing 400715, China.ORCID 0009-0009-3744-8013
Jianyu ZhuEngineering Research Center of Coptis Development and Utilization (Ministry of Education), School of Life Sciences, Southwest University, Chongqing 400715, China.ORCID 0009-0006-0317-2520
Chunyong SunEngineering Research Center of Coptis Development and Utilization (Ministry of Education), College of Pharmaceutical Sciences, Southwest University, Chongqing, 400715, China.ORCID 0000-0002-3673-3076
Jinyin ZhangEngineering Research Center of Coptis Development and Utilization (Ministry of Education), School of Life Sciences, Southwest University, Chongqing 400715, China.ORCID 0009-0001-9026-7088
Zhipeng YangEngineering Research Center of Coptis Development and Utilization (Ministry of Education), College of Pharmaceutical Sciences, Southwest University, Chongqing, 400715, China.ORCID 0009-0007-2994-5728
Jifei LiuEngineering Research Center of Coptis Development and Utilization (Ministry of Education), College of Pharmaceutical Sciences, Southwest University, Chongqing, 400715, China.ORCID 0009-0009-9892-1249
Yuan ZhouEngineering Research Center of Coptis Development and Utilization (Ministry of Education), School of Life Sciences, Southwest University, Chongqing 400715, China.ORCID 0009-0009-1027-6995
Zhenwei GuiEngineering Research Center of Coptis Development and Utilization (Ministry of Education), School of Life Sciences, Southwest University, Chongqing 400715, China.ORCID 0009-0003-6218-4562
Jingwei LiEngineering Research Center of Coptis Development and Utilization (Ministry of Education), School of Life Sciences, Southwest University, Chongqing 400715, China.ORCID 0009-0005-8167-6962
Hongmei WangEngineering Research Center of Coptis Development and Utilization (Ministry of Education), School of Life Sciences, Southwest University, Chongqing 400715, China.ORCID 0009-0002-8718-4561
Dan ShiDepartment of Pathology, Chongqing University Three Gorges Hospital, Chongqing University, Wanzhou 404100, Chongqing, China.ORCID 0009-0007-4415-1678
Qiang SongEngineering Research Center of Coptis Development and Utilization (Ministry of Education), School of Life Sciences, Southwest University, Chongqing 400715, China.ORCID 0000-0002-3151-4122
Xuegang LiEngineering Research Center of Coptis Development and Utilization (Ministry of Education), College of Pharmaceutical Sciences, Southwest University, Chongqing, 400715, China.ORCID 0000-0002-3016-719X
Rongkun TaoClinical Research Institute, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, 4221 South Xiang-An Road, Fujian 361102, China.ORCID 0000-0003-0176-3432
Hang MaEngineering Research Center of Coptis Development and Utilization (Ministry of Education), College of Pharmaceutical Sciences, Southwest University, Chongqing, 400715, China.ORCID 0000-0002-3730-8792
Xiaoli YeEngineering Research Center of Coptis Development and Utilization (Ministry of Education), School of Life Sciences, Southwest University, Chongqing 400715, China.ORCID 0000-0002-0904-0880
Funding
No grant is acknowledged in the PubMed record.
6 · The paper itself
Abstract
Metabolic dysfunction-associated steatohepatitis (MASH) is a prevalent and life-threatening liver disease with limited effective therapies, necessitating the urgent identification of previously unidentified molecular targets and effective pharmacologic agents. This study identifies aldo-keto reductase family 1 member B10 (AKR1B10) as the MASH hallmark, showing elevated expression in patient tissues and serum, correlating strongly with disease severity. Genetic ablation of
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.
TRIM29-dependent AKR1B10 degradation ameliorates MASH. · full record | Socratic