Evidence map›Paper›PMID 42566529›Full record

ArticleScience advances2026

APOE

Qintao Ge, Shengdong Ge, Zhongyuan Wang, Aihetaimujiang Anwaier, Jiahe Lu, Xi Tian, Yue Wang, Jianfeng Yang, Yonghao Chen, Hailiang Zhang and 3 more

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Qintao GeDepartment of Urology, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College; Qingdao Institute of Life Sciences, Fudan University, Shanghai, 200032, P.R. China.ORCID 0000-0001-5040-6699
Shengdong GeDepartment of Urology, The Fifth Affiliated Hospital, Southern Medical University, Guangzhou, 510900, China.ORCID 0000-0001-8187-9894
Zhongyuan WangDepartment of Urology, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College; Qingdao Institute of Life Sciences, Fudan University, Shanghai, 200032, P.R. China.ORCID 0000-0002-0257-8450
Aihetaimujiang AnwaierDepartment of Urology, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College; Qingdao Institute of Life Sciences, Fudan University, Shanghai, 200032, P.R. China.ORCID 0000-0002-0859-5171
Jiahe LuDepartment of Urology, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College; Qingdao Institute of Life Sciences, Fudan University, Shanghai, 200032, P.R. China.ORCID 0000-0002-3555-1991
Xi TianDepartment of Urology, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College; Qingdao Institute of Life Sciences, Fudan University, Shanghai, 200032, P.R. China.ORCID 0000-0003-1965-0647
Yue WangDepartment of Urology, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College; Qingdao Institute of Life Sciences, Fudan University, Shanghai, 200032, P.R. China.
Jianfeng YangDepartment of Urology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, P.R. China.ORCID 0000-0002-9526-2438
Yonghao ChenWest China Medical Center of Sichuan University, Chengdu, Sichuan, 610000, P.R. China.ORCID 0000-0003-0205-1816
Hailiang ZhangDepartment of Urology, Huadong Hospital, Fudan University, Shanghai 200030, China.ORCID 0000-0001-8408-7446
Dingwei YeDepartment of Urology, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College; Qingdao Institute of Life Sciences, Fudan University, Shanghai, 200032, P.R. China.ORCID 0000-0002-6761-5195
Shan-Chao ZhaoDepartment of Urology, The Fifth Affiliated Hospital, Southern Medical University, Guangzhou, 510900, China.ORCID 0000-0002-1162-8077
Wenhao XuDepartment of Urology, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College; Qingdao Institute of Life Sciences, Fudan University, Shanghai, 200032, P.R. China.ORCID 0000-0002-0660-9162

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tumor immune barriers (TIBs) are spatially organized stromal-immune niches that restrict lymphocyte entry. To explain persistent immune-checkpoint blockade (ICB) resistance in clear cell renal cell carcinoma (ccRCC), we mapped TIBs and defined a peritumoral variant built from POSTN

Indexed as

Apolipoproteins ECancer-Associated FibroblastsCarcinoma, Renal CellDrug Resistance, NeoplasmKidney NeoplasmsMacrophagesTumor-Associated MacrophagesAnimalsCell Adhesion MoleculesHumansImmune Checkpoint InhibitorsImmunotherapyMicePeriostinTransforming Growth Factor beta1Tumor MicroenvironmentApolipoproteins ECell Adhesion MoleculesImmune Checkpoint InhibitorsPeriostinPOSTN protein, humanTransforming Growth Factor beta1

Identifiers

PMID42566529
PMCPMC13450211

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.