ArticleEuropean stroke journal2026
Early rehabilitation initiation after aneurysmal subarachnoid haemorrhage: evaluation of mortality and functional outcomes.
Article in European stroke journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
introductionEvidence regarding the optimal timing of rehabilitation after aneurysmal subarachnoid haemorrhage (aSAH) remains limited. In this study, we aimed to evaluate clinical outcomes associated with initiating rehabilitation within 48 h after aneurysm securing. PATIENTS AND
methodsWe conducted a retrospective cohort study emulating a target trial using the Diagnosis Procedure Combination claims database (651 acute-care hospitals), which contains administrative data with limited clinical granularity. We included adults (≥18 years) with aSAH who underwent endovascular coiling or surgical clipping on hospital day 1 and had prestroke mRS scores of 0-2. Early rehabilitation was defined as initiation within 48 h after aneurysm securing; the comparator was initiation after 48 h. Using a clone-censoring-weighting approach, we estimated per-protocol hazard ratios for 30-day mortality and poor functional outcome (mRS scores of 3-6). Sensitivity analyses were conducted using alternative initiation thresholds (72, 96 and 120 h).
resultsAmong 7544 patients (mean age, 62.6 years; 69.7% women), crude 30-day mortality was 2.6% in the early initiation group and 1.5% in the deferred initiation group. In the per-protocol analysis, early rehabilitation was associated with higher 30-day mortality (hazard ratio [HR], 1.82; 95% CI, 1.21-2.63) and a higher risk of poor functional outcome (HR, 1.31; 95% CI, 1.08-1.55). This association was attenuated when "early" was defined after 72 h (mortality HR, 1.34; 95% CI, 0.87-2.07). DISCUSSION: Initiating rehabilitation within 48 h after aneurysm securing was associated with worse short-term outcomes, whereas deferring initiation until after 72 h attenuated the excess risk.
conclusionsThese findings suggest that the first 48 h may represent a higher-risk window for routine rehabilitation initiation in acute aSAH care.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.