Evidence map›Paper›PMID 42567209›Full record

ArticleJournal of affective disorders2026

Alcohol use disorder and childhood adversity in the association between polygenic risk and suicidality.

Victoria Wu, Xue-Jun Qin, Allison Ashley-Koch, Nathan A Kimbrel, Joel Gelernter, Anna R Docherty, Henry R Kranzler, Richard Feinn, Christal N Davis

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of affective disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Victoria WuQuinnipiac University Frank H. Netter School of Medicine, North Haven, CT, USA.
Xue-Jun QinDurham VA Medical Center, Cooperative Studies Program Epidemiology Center, Durham, NC, USA.
Allison Ashley-KochDuke University School of Medicine, Department of Biostatistics and Bioinformatics, Durham, NC, USA.
Nathan A KimbrelDurham VA Health Care System, VA VISN 6 Mid-Atlantic Mental Illness Research, Education, and Clinical Center, Durham, NC, USA; Duke University School of Medicine, Department of Psychiatry and Behavioral Sciences, Durham, NC, USA.
Joel GelernterYale School of Medicine, Departments of Psychiatry, Genetics, and Neuroscience, New Haven, CT, USA; Veterans Affairs Connecticut Healthcare Center, West Haven, CT, USA.
Anna R DochertyUniversity of Utah Spencer Fox Eccles School of Medicine, Salt Lake City, UT, USA; Huntsman Mental Health Institute, Salt Lake City, UT, USA; University of Utah Clinical and Translational Science Institute & the Center for Genomic Medicine, Salt Lake City, UT, USA.
Henry R KranzlerCrescenz VA Medical Center, Philadelphia, PA, USA; University of Pennsylvania Perelman School of Medicine, Department of Psychiatry, Philadelphia, PA, USA.
Richard FeinnQuinnipiac University Frank H. Netter School of Medicine, North Haven, CT, USA.
Christal N DavisCrescenz VA Medical Center, Philadelphia, PA, USA; University of Pennsylvania Perelman School of Medicine, Department of Psychiatry, Philadelphia, PA, USA. Electronic address: christal.davis@va.gov.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveSuicidal ideation (SI) and suicide attempt (SA) are both influenced by genetic, behavioral, and environmental factors. Alcohol use disorder (AUD) and adverse childhood experiences (ACEs) may mediate or moderate the effects of genetic liability for suicidality.

methodsUsing data from 10,275 participants (43.8% female; 47.2% African-like genetic ancestry [AFR], 52.8% European-like genetic ancestry [EUR]), we tested whether polygenic scores (PGS) for SI and SA predicted lifetime suicidality outcomes. We evaluated whether AUD partially accounted for these associations and ACEs moderated the direct and indirect associations.

resultsThe SA PGS was significantly associated with SA (AFR: b = 0.36, SE = 0.01; EUR: b = 0.17, SE = 0.01; both ps < 2e-16), but the SI PGS was not associated with SI (p > 0.55). AUD statistically mediated the association between the SA PGS and SA, accounting for approximately 2% of the total association in AFR individuals and 10% in EUR individuals (both ps < 2e-16). Notably, the proportion of the association that was accounted for by AUD decreased as ACEs exposure increased, from 4.30% to 0.54% in AFR individuals and from 13.31% to 3.44% in EUR individuals. In contrast, there was only very modest mediation and no moderated mediation for SI.

conclusionsParticularly among individuals with lower ACEs exposure, AUD accounted for a meaningful proportion of the association between genetic liability to SA and lifetime SA. These findings highlight different correlates across suicidality phenotypes and suggest potential clinical relevance for AUD in the association between genetic liability and SA.

Indexed as

Adverse Childhood ExperiencesAlcoholismMultifactorial InheritanceSuicidal IdeationSuicide, AttemptedAdultFemaleGenetic Predisposition to DiseaseGenetic Risk ScoreHumansMaleRisk FactorsWhite

Identifiers

PMID42567209

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.