Evidence map›Paper›PMID 42568180›Full record

ArticlePhysiological reports2026

Interplay between PNPLA3 genotype, liver steatosis, and cardiac remodeling in young adults: A magnetic resonance imaging study.

Nick S R Lan, Phillip E Melton, Amro Sehly, Leon A Adams, John K Olynyk, Oyekoya T Ayonrinde, Brendan Adler, Lawrence J Beilin, Trevor A Mori, Girish Dwivedi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiological reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Nick S R LanMedical School, The University of Western Australia, Perth, Western Australia, Australia.ORCID https://orcid.org/0000-0002-7222-7314
Phillip E MeltonMenzies Institute for Medical Research, College of Health and Medicine, University of Tasmania, Hobart, Tasmania, Australia.
Amro SehlyMedical School, The University of Western Australia, Perth, Western Australia, Australia.
Leon A AdamsMedical School, The University of Western Australia, Perth, Western Australia, Australia.
John K OlynykCurtin Medical Research Institute, Curtin University, Perth, Western Australia, Australia.
Oyekoya T AyonrindeMedical School, The University of Western Australia, Perth, Western Australia, Australia.
Brendan AdlerEnvision Medical Imaging, Perth, Western Australia, Australia.
Lawrence J BeilinMedical School, The University of Western Australia, Perth, Western Australia, Australia.
Trevor A MoriMedical School, The University of Western Australia, Perth, Western Australia, Australia.
Girish DwivediMedical School, The University of Western Australia, Perth, Western Australia, Australia.ORCID https://orcid.org/0000-0003-0717-740X

Funding

NHMRCRaine Medical Research Foundation
6 · The paper itself

Abstract

Steatotic liver disease (SLD) is associated with cardiovascular disease. The PNPLA3 rs738409C>G variant is a genetic determinant of liver fat accumulation. We investigated the association of the PNPLA3 rs738409C>G variant with cardiac structure and function in young adults, stratified by SLD status. Participants underwent genotyping at 17 years and liver and cardiac magnetic resonance imaging at 27 years. SLD was defined as volumetric liver fat fraction >3.55%. PNPLA3 rs738409 was analyzed primarily using a dominant genetic model (CC vs. CG/GG). Multivariable linear regression was used to evaluate the association between PNPLA3 rs738409C>G and cardiac parameters. Of 657 participants, 38.1% carried PNPLA3 rs738409C>G and 16.4% had SLD. Associations between PNPLA3 rs738409C>G and cardiac parameters were contingent on SLD status, with significant PNPLA3 × SLD interactions observed for left ventricular mass index (LVMi; p = 0.009), left ventricular end-diastolic volume index (LVEDVi; p = 0.015), and right ventricular end-diastolic volume index (RVEDVi; p = 0.049). PNPLA3 rs738409C>G was associated with greater LVMi (p = 0.014), LVEDVi (p = 0.005), and RVEDVi (p = 0.040) among individuals with SLD, but not without SLD. In this non-mechanistic observational study, PNPLA3 rs738409C>G was associated with subclinical cardiac remodeling only in the presence of SLD. These hypothesis-generating findings and any potential mechanisms require confirmation in future studies.

Indexed as

Fatty LiverLipaseMembrane ProteinsVentricular RemodelingAcyltransferasesAdolescentAdultFemaleGenotypeHumansMagnetic Resonance ImagingMalePhospholipases A2, Calcium-IndependentPolymorphism, Single NucleotideYoung AdultAcyltransferasesLipaseMembrane ProteinsPhospholipases A2, Calcium-IndependentPNPLA3 protein, humancardiaccardiometabolicgeneticslivermetabolicMRI

Identifiers

PMID42568180
PMCPMC13451627

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.