Evidence map›Paper›PMID 42568196›Full record

ArticlePhysiological reports2026

Supplemental oxygen induced cardiovascular pathophysiology in an end-of-life care model in mice.

Rohan Cheruku, Drithi Chidanand, Sashank Rangarajan, Nishank Rangarajan, Siva Kumar Panguluri

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiological reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Rohan CherukuDepartment of Pharmaceutical Sciences, Taneja College of Pharmacy, University of South Florida, Tampa, Florida, USA.
Drithi ChidanandDepartment of Pharmaceutical Sciences, Taneja College of Pharmacy, University of South Florida, Tampa, Florida, USA.
Sashank RangarajanDepartment of Pharmaceutical Sciences, Taneja College of Pharmacy, University of South Florida, Tampa, Florida, USA.
Nishank RangarajanDepartment of Pharmaceutical Sciences, Taneja College of Pharmacy, University of South Florida, Tampa, Florida, USA.
Siva Kumar PanguluriDepartment of Pharmaceutical Sciences, Taneja College of Pharmacy, University of South Florida, Tampa, Florida, USA.ORCID https://orcid.org/0000-0002-4242-8537

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Supplemental oxygen in critical care patients is associated with increased mortality. We previously reported hyperoxia-induces cardiac pathophysiology influenced by age, metabolic status, sex, and duration of exposure. The present study investigated the dose-dependent effects of oxygen on cardiac remodeling in very aged mice (>100 weeks), a model relevant to end-of-life physiology and clinical decision-making. Mice were exposed to graded oxygen concentrations or normal air for 72 h followed by comprehensive assessment of cardiac function and electrophysiology. Exposure to 70% O

Indexed as

HeartHyperoxiaOxygenTerminal CareVentricular RemodelingAnimalsCardiac OutputFemaleMaleMiceMice, Inbred C57BLOxygencardiac remodelingelectrical remodelingend‐of‐life caresex disparitiessupplemental oxygen

Identifiers

PMID42568196
PMCPMC13451652

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.