Evidence map›Paper›PMID 42568294›Full record

ReviewJournal of obesity2026

Experimental Models of Weight Cycling: A Narrative Review of Protocol Design and Metabolic Outcomes.

Isabela Macedo Lopes Vasques-Monteiro, Carolline Santos Miranda, Daniela de Barros Mucci, Bianca de Oliveira Saguie, Rafael Loureiro Simões, Fabiane Ferreira Martins, Vanessa Souza-Mello, Julio Beltrame Daleprane

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of obesity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Isabela Macedo Lopes Vasques-MonteiroDepartment of Basic and Experimental Nutrition, Laboratory for Studies of Interactions Between Nutrition and Genetics, LEING, Rio de Janeiro State University, Rio de Janeiro, Brazil, uerj.br.ORCID https://orcid.org/0000-0003-1729-3201
Carolline Santos MirandaDepartment of Basic and Experimental Nutrition, Laboratory for Studies of Interactions Between Nutrition and Genetics, LEING, Rio de Janeiro State University, Rio de Janeiro, Brazil, uerj.br.ORCID https://orcid.org/0000-0001-5488-0179
Daniela de Barros MucciDepartment of Basic and Experimental Nutrition, Laboratory for Studies of Interactions Between Nutrition and Genetics, LEING, Rio de Janeiro State University, Rio de Janeiro, Brazil, uerj.br.ORCID https://orcid.org/0000-0002-0467-2109
Bianca de Oliveira SaguieDepartment of Basic and Experimental Nutrition, Laboratory for Studies of Interactions Between Nutrition and Genetics, LEING, Rio de Janeiro State University, Rio de Janeiro, Brazil, uerj.br.ORCID https://orcid.org/0000-0002-2809-4569
Rafael Loureiro SimõesLaboratory of Molecular and Cellular Pharmacology, Roberto Alcântara Gomes Biology Institute, State University of Rio de Janeiro, Rio de Janeiro, Brazil, uerj.br.ORCID https://orcid.org/0000-0002-0403-2048
Fabiane Ferreira MartinsDepartment of Basic and Experimental Nutrition, Laboratory for Studies of Interactions Between Nutrition and Genetics, LEING, Rio de Janeiro State University, Rio de Janeiro, Brazil, uerj.br.ORCID https://orcid.org/0000-0002-3831-6604
Vanessa Souza-MelloLaboratory of Morphometry, Metabolism and Cardiovascular Diseases, Biomedical Center, Institute of Biology, Rio de Janeiro State University, Rio de Janeiro, Brazil, uerj.br.ORCID https://orcid.org/0000-0002-2510-9569
Julio Beltrame DalepraneDepartment of Basic and Experimental Nutrition, Laboratory for Studies of Interactions Between Nutrition and Genetics, LEING, Rio de Janeiro State University, Rio de Janeiro, Brazil, uerj.br.ORCID https://orcid.org/0000-0001-9608-3135

Funding

Conselho Nacional de Desenvolvimento Científico e TecnológicoCoordenação de Aperfeiçoamento de Pessoal de Nível Superior 001Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro-FAPERJ E-26/201.234/2022Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro-FAPERJ E-26/210.332/2022Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro-FAPERJ E-26/211.193/2021
6 · The paper itself

Abstract

Weight cycling (WC), characterized by repeated weight loss and regain, has been associated with adverse health effects, though evidence remains inconsistent. The aim of this review is evaluating WC protocols used in rodent studies, with a particular focus on how variations in experimental design and cycle periodization influence metabolic outcomes. All included studies were conducted in C57BL/6 mice, with protocols alternating between normocaloric and hypercaloric diets, in a variety of protocols, mainly in the periodization of cycles, diet composition, and sex of the animals. Despite evidence suggesting greater resistance to metabolic disorders associated with WC, studies in females are still scarce. Frequent cycling was associated with worsened metabolic outcomes, whereas prolonged weight-loss phases did not reverse obesity-induced alterations. Common findings included increased feed efficiency, loss of lean mass, persistent insulin resistance, and impaired glucose tolerance, alongside adipose tissue remodeling and low-grade inflammation. Divergent results appeared in relation to inflammation and lipid deposition in peripheral tissues. Collectively, the need for more standardized, sex-inclusive experimental designs will improve mechanistic insight and translational relevance.

Indexed as

ObesityWeight GainWeight LossAnimalsDisease Models, AnimalFemaleHumansInsulin ResistanceMaleMiceMice, Inbred C57BLResearch Designexperimental protocolsmetabolic dysfunctionobesogenic memorypreclinical modelsex differenceyo-yo effect

Identifiers

PMID42568294
PMCPMC13451937

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.