Evidence map›Paper›PMID 42568357›Full record

SynthesisFrontiers in cellular and infection microbiology2026

Global landscape and knowledge structure of research on pancreatitis and gut microbiota: a bibliometric analysis based on WoSCC and Scopus (2006 - 2025).

Huichuan Tian, Liangyue Wang, Zixuan He, Guanlu Li, Ziyi He, Gang Wei

Abstract readSystematic Review
In one paragraph

Synthesis in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Huichuan TianDepartment of Emergency, Xi'an Hospital of Traditional Chinese Medicine, Xi'an, China.
Liangyue WangFaculty of Chinese Medicine, Macau University of Science and Technology, Taipa, Macao SAR, China.
Zixuan HeSchool of Clinical Medicine, Hubei University of Medicine, Shiyan, Hubei, China.
Guanlu LiFaculty of Chinese Medicine, Macau University of Science and Technology, Taipa, Macao SAR, China.
Ziyi HeDepartment of Emergency, Xi'an Hospital of Traditional Chinese Medicine, Xi'an, China.
Gang WeiDepartment of Emergency, Xi'an Hospital of Traditional Chinese Medicine, Xi'an, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The research on pancreatitis and gut microbiota has expanded rapidly in recent years. Growing evidence suggests that gut dysbiosis may play an important role in pancreatic inflammation, intestinal barrier dysfunction and disease progression, but global research landscape, major contributors, knowledge structure and hotspots have not been fully defined. Materials and methods: Publications related to pancreatitis and gut microbiota were retrieved from the Web of Science Core Collection and Scopus. The search was conducted on Jan 5, 2026, and covered studies published between 2006 and 2025. Bibliometrix, VOSviewer, CiteSpace and Microsoft Excel were used to analyze the annual publication trends, journal sources, authors, countries, institutions, cited articles, co-cited references, keyword co-occurrence, thematic clustering, and time evolution. Results: The annual number of publications increased markedly from 2006 to 2025, with sustained acceleration after 2020. Pre- and post-2020 comparison suggested a shift from early clinical and intervention-oriented topics toward more mechanism-based and translational research, including gut microbiota, immune regulation, and multi-omics approaches. China contributed the most publications, followed by the United States. Citation and co-citation analyses identified major thematic groups related to acute pancreatitis, chronic pancreatitis, pancreatic homeostasis, dietary intervention, and microbiota-targeted research. Frequent keywords included human, gut microbiota, acute pancreatitis, intestinal flora, inflammation, dysbiosis, probiotics and chronic pancreatitis. Recent burst keywords were more closely related to bifidobacterium, short-chain fatty acids, metabolomics, acute lung injury, fecal analysis, and lipopolysaccharide, suggesting changing research attention toward mechanism-oriented and translational topics. Conclusion: This bibliometric analysis provides a detailed overview of global studies on pancreatitis and gut microbiota from 2006 to 2025. The field has expanded rapidly, and bibliometric patterns suggest increasing attention to mechanistic and translational investigations. Some highly co-cited references were related to pancreatic cancer, inflammatory bowel disease, microbial metabolites, immune regulation, and host-microbe interactions rather than pancreatitis itself, reflecting the broader knowledge base of this research field. Acute pancreatitis remained the most studied topic, while chronic pancreatitis, microbial metabolites, host response, and microbiota-targeted approaches gained increasing attention in recent years. Future research may shift from descriptive microbiota profiling to mechanism-oriented and translational studies.

Indexed as

BibliometricsGastrointestinal MicrobiomePancreatitisAnimalsDysbiosisHumansbibliometric analysischronic pancreatitisCiteSpacedysbiosisgut microbiotamicrobial metabolitespancreatitisVOSviewer

Identifiers

PMID42568357
PMCPMC13447049

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.