ArticleFrontiers in neurology
Development and external validation of a machine learning model based on multimodal dynamic data for predicting shunt-dependent hydrocephalus after aneurysmal subarachnoid hemorrhage: a dual-center retrospective cohort study.
Article in Frontiers in neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To develop and externally validate a machine learning model for predicting shunt-dependent hydrocephalus (SDHC) after aneurysmal subarachnoid hemorrhage (aSAH) using multimodal dynamic data. Methods: This dual-center retrospective study enrolled aSAH patients from Mindong Hospital (development cohort, 2018-2025) and Putian University Hospital (external validation cohort, 2016-2025). Using a day-21 landmark design, static baseline variables, weekly dynamic parameters, and clinical interventions were collected. Derived features capturing ventricular dynamics, intracranial pressure fluctuations, and inflammatory trajectories were engineered. Three models were compared using nested cross-validation. Performance was evaluated by AUC, AUPRC, Brier score, decision curve analysis, and SHAP analysis. Derived dynamic features characterizing ventricular expansion, intracranial pressure fluctuation, and inflammatory trajectories were engineered, and an ablation analysis was performed to quantify their incremental predictive contribution beyond static baseline variables. Results: The development cohort included 228 patients (SDHC 21.9%); external validation included 102 patients (SDHC 23.5%). Random forest achieved optimal internal validation performance (AUC 0.894, AUPRC 0.676, Brier 0.112). At threshold 0.30, sensitivity and specificity were 0.920 and 0.840. External validation showed robust generalizability (AUC 0.867, sensitivity 0.875, specificity 0.859). Risk stratification demonstrated SDHC rates of 5.3, 35.7, and 64.7% in low-, intermediate-, and high-risk groups ( Conclusion: The random forest model integrating multimodal dynamic data accurately predicts SDHC after aSAH with strong external validity; ablation analysis confirmed that incorporating dynamic features significantly improved discrimination (AUC 0.894 vs. 0.831 for the static-only model, ΔAUC = 0.063,
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