ArticleFrontiers in physiology2026
Claudin-3 is expressed at the
Article in Frontiers in physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Claudin-3 is a tight junction protein expressed in the distal nephron, notably in the thick ascending limb of Henle's loop and the distal convoluted tubule, where it acts as an aldosterone-regulated paracellular barrier to sodium and chloride transport. Here, we demonstrate that claudin-3 knockout (KO) mice exhibit an unexpected diet-dependent alteration in glomerular filtration rate (GFR): under a normal sodium (NS) diet, GFR decreases significantly, whereas under a low sodium (LS) diet, GFR increases paradoxically compared with wild-type controls. To identify the underlying mechanism, we examined claudin-3 expression in the
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