Evidence map›Paper›PMID 42568539›Full record

ArticleFrontiers in cellular and infection microbiology2026

Genomic and transcriptomic analyses reveal a Gifsy-1 prophage-encoded virulence module associated with enhanced epithelial adhesion of

Ling Zhu, Xiangchen Li, Lili Zheng, Lihua Zhou, Zhenfa Chen, Yibin Lin, Jianhua Zhu, Junshun Gao, Junli Gao, Yunxiang Cai and 1 more

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Article in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ling Zhu *Department of Clinical Laboratory, First Affiliated Hospital of Huzhou Normal University, The First People's Hospital of Huzhou, Huzhou, China.
Xiangchen Li *Cosmos Wisdom Mass Spectrometry Center of Zhejiang University Medical School, Hangzhou, China.
Lili ZhengDepartment of Clinical Laboratory, First Affiliated Hospital of Huzhou Normal University, The First People's Hospital of Huzhou, Huzhou, China.
Lihua ZhouDepartment of Clinical Laboratory, First Affiliated Hospital of Huzhou Normal University, The First People's Hospital of Huzhou, Huzhou, China.
Zhenfa ChenDepartment of Clinical Laboratory, First Affiliated Hospital of Huzhou Normal University, The First People's Hospital of Huzhou, Huzhou, China.
Yibin LinSchool of Medicine, Huzhou Normal University, Huzhou, China.
Jianhua ZhuCosmos Wisdom Mass Spectrometry Center of Zhejiang University Medical School, Hangzhou, China.
Junshun GaoCosmos Wisdom Mass Spectrometry Center of Zhejiang University Medical School, Hangzhou, China.
Junli GaoCosmos Wisdom Mass Spectrometry Center of Zhejiang University Medical School, Hangzhou, China.
Yunxiang CaiDepartment of Clinical Laboratory, First Affiliated Hospital of Huzhou Normal University, The First People's Hospital of Huzhou, Huzhou, China.
Xinhua QiangDepartment of Clinical Laboratory, First Affiliated Hospital of Huzhou Normal University, The First People's Hospital of Huzhou, Huzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Non-typhoidal Methods: A 7.5-year surveillance study (2017-2024) was conducted using NTS isolates from patients with acute diarrheal illness in Huzhou, China. Quantitative IEC-6 cell-based adhesion and invasion assays, comparative genomics, transcriptomic profiling, and protein-protein interaction network analysis were integrated to compare the dominant sequence types (STs). Results: Among 188 NTS isolates, 35 serotypes and 36 STs were identified. Three STs predominated: ST34 (26.1%, mainly monophasic Discussion: These findings identify an intact Gifsy-1 prophage encoding GogB and SteE/SarA as a candidate module associated with enhanced epithelial adhesion in ST34, a dominant NTS lineage with an extensive antimicrobial resistance repertoire.

Indexed as

Bacterial AdhesionEpithelial CellsProphagesSalmonellaSalmonella InfectionsAnti-Bacterial AgentsCell LineChinaGene Expression ProfilingGenomicsHumansTranscriptomeVirulenceVirulence FactorsAnti-Bacterial AgentsVirulence Factorsantimicrobial resistancecomparative genomicsGifsy-1 prophageSalmonellaST34transcriptomicsvirulence

Identifiers

PMID42568539
PMCPMC13447223

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.