ArticleFrontiers in human neuroscience2026
Prefrontal activation and connectivity during verbal fluency in autism Spectrum disorder: an fNIRS study.
Article in Frontiers in human neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: The neural mechanisms behind varying cognitive ability in children with Autism Spectrum Disorder (ASD) remain unclear. This study compared cortical activation and brain connectivity across ASD subgroups stratified by Full-Scale Intelligence Quotient (FSIQ). Methods: Sixty-four children with ASD were divided into two groups based on their FSIQ scores: Group 1 ( Results: Compared to Group 2, Group 1 showed significantly stronger cortical activation in channels 1 and 2 [corresponding to the inferior frontal gyrus (IFG)] ( Conclusion: Our findings provide neurofunctional evidence for the association between cognitive resource capacity and verbal-executive processing in ASD. ASD children with lower FSIQ exhibited lower prefrontal activation and lower functional connectivity during the VFT, particularly within the IFG, frontopolar cortex (FPC), and dorsolateral prefrontal cortex (DLPFC). These results underscore the utility of fNIRS in delineating distinct neurocognitive profiles within ASD and highlight the IFG as a key region where neural activity correlates with both cognitive ability and language output, offering a potential target for mechanism-based intervention strategies.
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