Evidence map›Paper›PMID 42568713›Full record

ArticleMedComm2026

Proteomic and Phosphoproteomic Characteristics of Multiple Brain Regions in Rhesus Macaques After SARS-CoV-2 Infection.

Qiaochu Wang, Yanan Zhou, Tao Ding, Yan Sun, Yehong Yang, Yue Wu, Jiangfeng Liu, Shuaiyao Lu, Juntao Yang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in MedComm, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Qiaochu WangState Key Laboratory of Common Mechanism Research for Major Diseases, Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China.
Yanan ZhouState Key Laboratory of Common Mechanism Research for Major Diseases, Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China.
Tao DingState Key Laboratory of Common Mechanism Research for Major Diseases, Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China.
Yan SunState Key Laboratory of Common Mechanism Research for Major Diseases, Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China.
Yehong YangState Key Laboratory of Common Mechanism Research for Major Diseases, Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China.
Yue WuState Key Laboratory of Common Mechanism Research for Major Diseases, Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China.
Jiangfeng LiuState Key Laboratory of Common Mechanism Research for Major Diseases, Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China.
Shuaiyao LuNational Kunming High-level Biosafety Primate Research Center, Institute of Medical Biology Chinese Academy of Medical Sciences and Peking Union Medical College Yunnan China.ORCID https://orcid.org/0000-0003-1675-9735
Juntao YangState Key Laboratory of Common Mechanism Research for Major Diseases, Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The SARS-CoV-2 Omicron variant is more contagious than the original Alpha variant and can still cause neurological symptoms, including cognitive impairment. To gain a deeper understanding of the molecular mechanisms underlying these neurological effects, this study was conducted. Proteomic and phosphoproteomic analyses were carried out utilizing LC-MS/MS. Samples included brainstem, cerebellum, frontal lobe, occipital lobe, parietal lobe, and temporal lobe from SARS-CoV-2 Omicron-infected and noninfected control rhesus macaques. Infection with Omicron resulted in inflammatory responses across all six brain regions, and significant regional-specific molecular alterations were observed. Proteomic and phosphoproteomic analyses revealed extensive abnormalities in immune activation, synaptic function, DNA repair, and signaling pathways across different brain regions. We further predicted key kinases and identified candidate proteins with significantly altered expression. This study reveals region-specific inflammatory and signaling signatures in the brain following Omicron infection. The recognized kinases and proteins with abnormal regulation serve as potential candidates for drug discovery. This can aid in formulating new therapeutic approaches for neurological issues related to COVID-19.

Indexed as

brainneurological consequencesproteomicrhesus macaquesSARS‐CoV‐2 Omicron strain

Identifiers

PMID42568713
PMCPMC13448139

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.