ArticleRSC advances2026
Heterocyclic chemistry meets wound care: novel
Article in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Biofilm-associated infections represent a major challenge in the treatment of antimicrobial-resistant pathogens, particularly in chronic and wound-related infections where bacterial adherence and persistence reduce therapeutic efficacy. To address this issue, we report a rapid, economical, and efficient one-pot three-component synthesis of 19 novel bis(trifluoromethyl)-dimethyl-substituted dihydro-pyrrol-2-one derivatives, providing a promising scaffold for the development of new antimicrobial and anti-biofilm agents. The structures of the synthesized compounds were confirmed by NMR, FT-IR, MALDI-MS, and X-ray diffraction analyses. ADMET prediction revealed highly similar pharmacokinetic profiles across the series, supporting the suitability of this scaffold for further medicinal chemistry optimization. Biological evaluation demonstrated that antimicrobial activity was strongly influenced by the nature of the substituents. Compounds 4i, 4j, 4l, 4n, 4o, 4p, and 4t exhibited the highest activity against
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.