Evidence map›Paper›PMID 42568949›Full record

ReviewJournal of orthopaedic translation2026

Ferroptosis in skeletal muscle: from molecular mechanisms to therapeutic interventions.

Kejin Ren, Yijia An, Kaili Zhou, Xiaofang Cheng, Tiantian Meng, Cencen Li, Haixia Xu, Pengpeng Zhang, Yongjie Xu

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of orthopaedic translation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kejin RenCollege of Life Science, Xinyang Normal University, Xinyang, 464000, China.
Yijia AnCollege of Life Science, Xinyang Normal University, Xinyang, 464000, China.
Kaili ZhouCollege of Life Science, Xinyang Normal University, Xinyang, 464000, China.
Xiaofang ChengCollege of Life Science, Xinyang Normal University, Xinyang, 464000, China.
Tiantian MengCollege of Life Science, Xinyang Normal University, Xinyang, 464000, China.
Cencen LiCollege of Life Science, Xinyang Normal University, Xinyang, 464000, China.
Haixia XuCollege of Life Science, Xinyang Normal University, Xinyang, 464000, China.
Pengpeng ZhangCollege of Life Science, Xinyang Normal University, Xinyang, 464000, China.
Yongjie XuCollege of Life Science, Xinyang Normal University, Xinyang, 464000, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ferroptosis is an iron-dependent, non-apoptotic form of regulated cell death driven by lethal lipid peroxidation and has emerged as a pivotal regulator of skeletal muscle physiology and pathology. This review systematically delineates the core molecular machinery of ferroptosis, including the system Xc The translational potential of this article: This review establishes ferroptosis as a convergent pathogenic mechanism across muscle disorders, offering a framework for patient stratification by ferrototic signatures. It synthesizes preclinical evidence for pharmacologic inhibitors, natural products, and gene-based interventions, while critically evaluating clinical feasibility, safety, and dosing. A tiered translational roadmap from biomarker validation to early-phase trials is proposed to accelerate bench-to-bedside development.

Indexed as

FerroptosisMolecular mechanismSatellite cellsSkeletal muscleSkeletal muscle diseaseTherapeutic intervention

Identifiers

PMID42568949
PMCPMC13448446

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.