Evidence map›Paper›PMID 42568989›Full record

ArticleFrontiers in medicine2026

A multifactorial approach to tacrolimus therapeutic drug monitoring in complex liver transplantation: a case report.

Limian Liang, Tian He, Yiming Huang, Min Wu, Jiajia Liu, Shiyun Chen, Wei Li, Miaona Liu, Pusen Wang

Abstract readCase Reports
In one paragraph

Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Limian Liang *Department of Pharmacy, Shenzhen Third People's Hospital, Shenzhen, Guangdong, China.
Tian He *Department of Pharmacy, Shenzhen Third People's Hospital, Shenzhen, Guangdong, China.
Yiming Huang *Department of Liver Surgery and Organ Transplantation Center, Shenzhen Third People's Hospital, Shenzhen, Guangdong, China.
Min WuDepartment of Pharmacy, Shenzhen Third People's Hospital, Shenzhen, Guangdong, China.
Jiajia LiuDepartment of Pharmacy, Shenzhen Third People's Hospital, Shenzhen, Guangdong, China.
Shiyun ChenDepartment of Pharmacy, Shenzhen Third People's Hospital, Shenzhen, Guangdong, China.
Wei LiDepartment of Pharmacy, Shenzhen Third People's Hospital, Shenzhen, Guangdong, China.
Miaona LiuDepartment of Pharmacy, Shenzhen Third People's Hospital, Shenzhen, Guangdong, China.
Pusen WangDepartment of Liver Surgery and Organ Transplantation Center, Shenzhen Third People's Hospital, Shenzhen, Guangdong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This case describes a structured, multifactorial framework for interpreting tacrolimus therapeutic drug monitoring in a complex liver transplant recipient, with hypothesis-generating implications for clinical decision-making. This was a single-patient case report with serial therapeutic drug monitoring and longitudinal clinical follow-up. The clinical course of a 33-year-old male liver transplant recipient was documented in detail. During a 90-day hospitalization, the patient underwent two liver transplantations and experienced abnormal liver function, progressive anemia, and severe diarrhea, accompanied by marked fluctuations in tacrolimus trough concentrations (C

Indexed as

complex casesdose adjustmenthematocritliver transplantationpharmacokineticstacrolimustherapeutic drug monitoring

Identifiers

PMID42568989
PMCPMC13448784

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.